MCMCB Pro
D89.43

D89.43Secondary mast cell activation

Billable / specific codeICD-10-CM

D89.43 is a billable, specific ICD-10-CM code for secondary mast cell activation. It is valid for submission on a claim.

Code also

Both codes may be needed to describe the encounter fully. Sequencing depends on the reason for the visit.

  • underlying etiology, if known

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Secondary mast cell activation syndrome

Risk adjustment

D89.43 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

D89.43 is named in 15 Medicare coverage policies 15 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A56638Billing and Coding: Gastrointestinal Pathogen (GIP) Panels Utilizing Multiplex Nucleic Acid Amplification Techniques (NAATs)
  • A56642Billing and Coding: Gastrointestinal Pathogen (GIP) Panels Utilizing Multiplex Nucleic Acid Amplification Techniques (NAATs)
  • A57689Billing and Coding: Lab: Flow Cytometry
  • A58575Billing and Coding: Respiratory Pathogen Panel Testing

How D89.43 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to D89.43.

  • Activationmast cellsecondary

Related codes at this level

Codes that share D89.4. If D89.43 is not quite right, the correct code is usually one of these.

Questions about D89.43

Is D89.43 a billable ICD-10-CM code?
Yes. D89.43 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does D89.43 sit in the tabular list?
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Certain disorders involving the immune mechanism (D80-D89).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.