MCMCB Pro
C88.3

C88.3Immunoproliferative small intestinal disease

Non-billable headerICD-10-CM

C88.3 is a non-billable header ICD-10-CM code for immunoproliferative small intestinal disease. It cannot be billed on its own: choose one of the more specific child codes below.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Alpha heavy chain disease
  • Mediterranean lymphoma

Risk adjustment

C88.3 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

C88.3 is named in 1 Medicare coverage policy 1 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A59491Billing and Coding: Genetic Testing for Oncology

Code to one of these instead C88.3

2 child codes. Green means billable.

Related codes at this level

Codes that share C88. If C88.3 is not quite right, the correct code is usually one of these.

Questions about C88.3

Is C88.3 a billable ICD-10-CM code?
No. C88.3 is a non-billable header code. Code to a higher level of specificity using one of its child codes.
Where does C88.3 sit in the tabular list?
Neoplasms (C00-D49), in the block Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.