MCMedicalCodingSoftware
Z79.81

Z79.81: Long term (current) use of agents affecting estrogen receptors and estrogen levels

Non-billable headerICD-10-CM

Z79.81 is a non-billable header ICD-10-CM code for long term (current) use of agents affecting estrogen receptors and estrogen levels. It cannot be billed on its own: choose one of the more specific child codes below.

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • hormone replacement therapy (Z79.890)

Code first

The underlying condition must be sequenced before this code.

  • , if applicable:
  • malignant neoplasm of breast (C50.-)
  • malignant neoplasm of prostate (C61)

Use additional code

Add a secondary code to capture the detail described below.

  • code, if applicable, to identify:
  • estrogen receptor positive status (Z17.0)
  • family history of breast cancer (Z80.3)
  • genetic susceptibility to malignant neoplasm (cancer) (Z15.0-)
  • personal history of breast cancer (Z85.3)
  • personal history of prostate cancer (Z85.46)
  • postmenopausal status (Z78.0)

Excludes2 inherited from the categories above Z79.81

Not part of this code, but both may be coded when both are present.

Written on Z79: Long term (current) drug therapy

  • drug abuse and dependence (F11-F19)
  • drug use complicating pregnancy, childbirth, and the puerperium (O99.32-)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead Z79.81

3 child codes. Green means billable.

Other codes under Z79.8

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.