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Z79.818

Z79.818: Long term (current) use of other agents affecting estrogen receptors and estrogen levels

Billable / specific codeICD-10-CMPOA exempt

Z79.818 is a billable, specific ICD-10-CM code for long term (current) use of other agents affecting estrogen receptors and estrogen levels. It is valid for submission on a claim.

Check Z79.818 with the rest of the claim: free scrubber

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Long term (current) use of estrogen receptor downregulators
  • Long term (current) use of fulvestrant (Faslodex)
  • Long term (current) use of gonadotropin-releasing hormone (GnRH) agonist
  • Long term (current) use of goserelin acetate (Zoladex)
  • Long term (current) use of leuprolide acetate (leuprorelin) (Lupron)
  • Long term (current) use of megestrol acetate (Megace)

Excludes1 inherited from the categories above Z79.818

A category’s note binds every code beneath it.

Written on Z79.81: Long term (current) use of agents affecting estrogen receptors and estrogen levels

  • hormone replacement therapy (Z79.890)

Excludes2 inherited from the categories above Z79.818

Not part of this code, but both may be coded when both are present.

Written on Z79: Long term (current) drug therapy

  • drug abuse and dependence (F11-F19)
  • drug use complicating pregnancy, childbirth, and the puerperium (O99.32-)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

Z79.818 is named in 6 Medicare coverage policies: 6 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A52399Billing and Coding: Denosumab (Prolia®, Xgeva®, Jubbonti®) and biosimilars
  • A57132Billing and Coding: Bone Mass Measurement
  • A57718Billing and Coding: Vitamin D Assay Testing
  • A57736Billing and Coding: Vitamin D Assay Testing

Alphabetic index entries that lead here

  • Long-term›agents affecting estrogen receptors and estrogen levels NEC
  • Long-term›estrogen receptor downregulators
  • Long-term›fulvestrant(Faslodex)
  • Long-term›gonadotropin-releasing hormone agonist(GnRH)
  • Long-term›goserelin acetate(Zoladex)
  • Long-term›leuprolide acetate(leuprorelin) (Lupron)
  • Long-term›megestrol acetate(Megace)
  • Therapy›drug, long-term›agents affecting estrogen receptors and estrogen levels NEC
  • Therapy›drug, long-term›estrogen receptor downregulators
  • Therapy›drug, long-term›fulvestrant(Faslodex)
  • Therapy›drug, long-term›gonadotropin-releasing hormone agonist(GnRH)
  • Therapy›drug, long-term›goserelin acetate(Zoladex)

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under Z79.81

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.