MCMedicalCodingSoftware
T80.69

T80.69: Other serum reaction due to other serum

Non-billable headerICD-10-CM

T80.69 is a non-billable header ICD-10-CM code for other serum reaction due to other serum. It cannot be billed on its own: choose one of the more specific child codes below. This code also requires a 7th character before it is complete.

This code requires a 7th character

The appropriate 7th character is to be added to each code from category T80

A
initial encounter
D
subsequent encounter
S
sequela

Code also

Both codes may be needed to describe the encounter fully. Sequencing depends on the reason for the visit.

  • , if applicable, arthropathy in hypersensitivity reactions classified elsewhere (M36.4)

Excludes2 inherited from the categories above T80.69

Not part of this code, but both may be coded when both are present.

Written on T80.6: Other serum reactions

Written on T80: Complications following infusion, transfusion and therapeutic injection

  • bone marrow transplant rejection (T86.01)
  • febrile nonhemolytic transfusion reaction (R50.84)
  • fluid overload due to transfusion (E87.71)
  • posttransfusion purpura (D69.51)
  • transfusion associated circulatory overload (TACO) (E87.71)
  • transfusion (red blood cell) associated hemochromatosis (E83.111)
  • transfusion related acute lung injury (TRALI) (J95.84)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Alphabetic index entries that lead here

  • Allergy, allergic›serum
  • Disease, diseased›serum NEC
  • Effect, adverse›serum NEC
  • Intoxication›serum
  • Neuritis›serum
  • Protein›sickness
  • Rash›serum
  • Reaction›serum
  • Serum›allergy, allergic reaction
  • Serum›arthritis
  • Serum›complication or reaction NEC
  • Serum›disease NEC

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead T80.69

3 child codes. Green means billable.

Other codes under T80.6

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.