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D84.81

D84.81: Immunodeficiency due to conditions classified elsewhere

Billable / specific codeICD-10-CM

D84.81 is a billable, specific ICD-10-CM code for immunodeficiency due to conditions classified elsewhere. It is valid for submission on a claim.

Check D84.81 with the rest of the claim: free scrubber

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • certain disorders involving the immune mechanism (D80-D83, D84.0, D84.1, D84.9)
  • human immunodeficiency virus [HIV] disease (B20)

Code first

The underlying condition must be sequenced before this code.

  • underlying condition, such as:
  • chromosomal abnormalities (Q90-Q99)
  • diabetes mellitus (E08-E13)
  • malignant neoplasms (C00-C96)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

D84.81 is named in 5 Medicare coverage policies: 5 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A56464Billing and Coding: Flow Cytometry
  • A56638Billing and Coding: Gastrointestinal Pathogen (GIP) Panels Utilizing Multiplex Nucleic Acid Amplification Techniques (NAATs)
  • A56642Billing and Coding: Gastrointestinal Pathogen (GIP) Panels Utilizing Multiplex Nucleic Acid Amplification Techniques (NAATs)
  • A57044Billing and Coding: Removal of Benign Skin Lesions

Alphabetic index entries that lead here

  • Immunodeficiency›due to›conditions classified elsewhere

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under D84.8

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.