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D75.81

D75.81: Myelofibrosis

Billable / specific codeICD-10-CM

D75.81 is a billable, specific ICD-10-CM code for myelofibrosis. It is valid for submission on a claim.

Check D75.81 with the rest of the claim: free scrubber

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • acute myelofibrosis (C94.4-)
  • idiopathic myelofibrosis (D47.1)
  • leukoerythroblastic anemia (D61.82)
  • myelofibrosis with myeloid metaplasia (D47.4)
  • myelophthisic anemia (D61.82)
  • myelophthisis (D61.82)
  • primary myelofibrosis (D47.1)

Code first

The underlying condition must be sequenced before this code.

  • the underlying disorder, such as:
  • malignant neoplasm of breast (C50.-)

Use additional code

Add a secondary code to capture the detail described below.

  • code, if applicable, for associated therapy-related myelodysplastic syndrome (D46.-)
  • code for adverse effect, if applicable, to identify drug (T45.1X5)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Myelofibrosis NOS
  • Secondary myelofibrosis NOS

Excludes2 inherited from the categories above D75.81

Not part of this code, but both may be coded when both are present.

Written on D75: Other and unspecified diseases of blood and blood-forming organs

  • acute lymphadenitis (L04.-)
  • chronic lymphadenitis (I88.1)
  • enlarged lymph nodes (R59.-)
  • hypergammaglobulinemia NOS (D89.2)
  • lymphadenitis NOS (I88.9)
  • mesenteric lymphadenitis (acute) (chronic) (I88.0)

Other codes that can never be billed with D75.81

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • C94.4Acute panmyelosis with myelofibrosis
  • D47.1Chronic myeloproliferative disease
  • D61.82Myelophthisis
  • M85.8Other specified disorders of bone density and structure

Risk adjustment

D75.81 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 19 Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers1.798 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score. Look up the whole chart to see which of its HCCs the hierarchy would zero.

Medicare coverage

D75.81 is named in 38 Medicare coverage policies: 38 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A52986Billing and Coding: Biomarkers for Oncology
  • A55717Billing and Coding: Lab: Flow Cytometry
  • A56199Billing and Coding: Molecular Pathology Procedures
  • A56421Billing and Coding: CT of the Abdomen and Pelvis

Alphabetic index entries that lead here

  • Myelofibrosis
  • Anemia›myelofibrosis
  • Myelofibrosis›secondary
  • Osteosclerosis›myelofibrosis

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under D75.8

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.