D75.81 — Myelofibrosis
D75.81 is a billable, specific ICD-10-CM code for myelofibrosis. It is valid for submission on a claim.
Excludes1 — never code together
These conditions cannot occur together. Billing both on the same encounter is a denial.
Code first
The underlying condition must be sequenced before this code.
- the underlying disorder, such as:
- malignant neoplasm of breast (C50.-)
Use additional code
Add a secondary code to capture the detail described below.
Inclusion terms
Alternative wordings a physician may use in the chart for this same code.
- Myelofibrosis NOS
- Secondary myelofibrosis NOS
Excludes2 inherited from the categories above D75.81
Also inherited, and the opposite of Excludes1: these conditions are not part of D75.81, but a patient can have both, so you may code both.
Other codes that can never be billed with D75.81
These codes carry an Excludes1 note pointing at D75.81. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading D75.81 alone.
Risk adjustment
D75.81 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:
- HCC 19 Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers1.798 RAF
Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.
Medicare coverage
D75.81 is named in 61 Medicare coverage policies — 61 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.
- A52986Billing and Coding: Biomarkers for Oncology
- A55717Billing and Coding: Lab: Flow Cytometry
- A56199Billing and Coding: Molecular Pathology Procedures
- A56199Billing and Coding: Molecular Pathology Procedures
How D75.81 is indexed
Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to D75.81.
- Myelofibrosis
- Anemia›myelofibrosis
- Myelofibrosis›secondary
- Osteosclerosis›myelofibrosis
Code history
D75.81 has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.
Related codes at this level
Codes that share D75.8. If D75.81 is not quite right, the correct code is usually one of these.
Questions about D75.81
- Is D75.81 a billable ICD-10-CM code?
- Yes. D75.81 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
- Where does D75.81 sit in the tabular list?
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Other disorders of blood and blood-forming organs (D70-D77).
- What cannot be coded together with D75.81?
- D75.81 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter.