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D59.31

D59.31Infection-associated hemolytic-uremic syndrome

Billable / specific codeICD-10-CM

D59.31 is a billable, specific ICD-10-CM code for infection-associated hemolytic-uremic syndrome. It is valid for submission on a claim.

Use additional code

Add a secondary code to capture the detail described below.

  • code to identify associated infection, such as :
  • E. coli infection (B96.2-)
  • Human immunodeficiency virus [HIV] disease (B20)
  • Pneumococcal meningitis (G00.1)
  • Pneumococcal pneumonia (J13)
  • Sepsis due to Streptococcus pneumoniae (A40.3)
  • Shigella dysenteriae (A03.9)
  • Streptococcus pneumoniae as the cause of diseases classified elsewhere (B95.3)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Shiga toxin-producing E. coli [STEC] related hemolytic uremic syndrome
  • Typical hemolytic uremic syndrome

Risk adjustment

D59.31 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 109 Acquired Hemolytic, Aplastic, and Sideroblastic Anemias1.144 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

D59.31 is named in 9 Medicare coverage policies 9 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A54548Billing and Coding: Eculizumab, and Biosimilars: EPYSQLI®-eculizumab-aagh, and BKEMV™-eculizumab-aeeb
  • A58710Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
  • A58710Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
  • A58720Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing

How D59.31 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to D59.31.

  • Syndromehemolytic-uremicinfection-associated
  • Syndromehemolytic-uremicShiga toxin-producing E. coli [STEC] related
  • Syndromehemolytic-uremictypical
  • Syndromehemolytic-uremicatypicalinfection-associated

Related codes at this level

Codes that share D59.3. If D59.31 is not quite right, the correct code is usually one of these.

Questions about D59.31

Is D59.31 a billable ICD-10-CM code?
Yes. D59.31 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does D59.31 sit in the tabular list?
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Hemolytic anemias (D55-D59).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.