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D59.31

D59.31: Infection-associated hemolytic-uremic syndrome

Billable / specific codeICD-10-CM

D59.31 is a billable, specific ICD-10-CM code for infection-associated hemolytic-uremic syndrome. It is valid for submission on a claim.

Check D59.31 with the rest of the claim: free scrubber

Use additional code

Add a secondary code to capture the detail described below.

  • code to identify associated infection, such as :
  • E. coli infection (B96.2-)
  • Human immunodeficiency virus [HIV] disease (B20)
  • Pneumococcal meningitis (G00.1)
  • Pneumococcal pneumonia (J13)
  • Sepsis due to Streptococcus pneumoniae (A40.3)
  • Shigella dysenteriae (A03.9)
  • Streptococcus pneumoniae as the cause of diseases classified elsewhere (B95.3)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Shiga toxin-producing E. coli [STEC] related hemolytic uremic syndrome
  • Typical hemolytic uremic syndrome

Risk adjustment

D59.31 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 109 Acquired Hemolytic, Aplastic, and Sideroblastic Anemias1.144 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score. Look up the whole chart to see which of its HCCs the hierarchy would zero.

Medicare coverage

D59.31 is named in 5 Medicare coverage policies: 5 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A54548Billing and Coding: Eculizumab, and Biosimilars: EPYSQLI®-eculizumab-aagh, and BKEMV™-eculizumab-aeeb
  • A58710Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
  • A58720Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
  • A58747Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing

Alphabetic index entries that lead here

  • Syndrome›hemolytic-uremic›infection-associated
  • Syndrome›hemolytic-uremic›Shiga toxin-producing E. coli [STEC] related
  • Syndrome›hemolytic-uremic›typical
  • Syndrome›hemolytic-uremic›atypical›infection-associated

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under D59.3

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.