MCMedicalCodingSoftware
D57.21

D57.21: Sickle-cell/Hb-C disease with crisis

Non-billable headerICD-10-CM

D57.21 is a non-billable header ICD-10-CM code for sickle-cell/hb-c disease with crisis. It cannot be billed on its own: choose one of the more specific child codes below.

Excludes1 inherited from the categories above D57.21

A category’s note binds every code beneath it.

Written on D57: Sickle-cell disorders

  • other hemoglobinopathies (D58.-)

Other codes that can never be billed with D57.21

Their own Excludes1 notes name this code, so the conflict is not listed above.

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead D57.21

6 child codes. Green means billable.

Other codes under D57.2

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.