MCMedicalCodingSoftware
D53.0

D53.0: Protein deficiency anemia

Billable / specific codeICD-10-CM

D53.0 is a billable, specific ICD-10-CM code for protein deficiency anemia. It is valid for submission on a claim.

Check D53.0 with the rest of the claim: free scrubber

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • Lesch-Nyhan syndrome (E79.1)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Amino-acid deficiency anemia
  • Orotaciduric anemia

Other codes that can never be billed with D53.0

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • E79Disorders of purine and pyrimidine metabolism

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

D53.0 is named in 1 Medicare coverage policy: 1 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A56464Billing and Coding: Flow Cytometry

Alphabetic index entries that lead here

  • Amino-acid disorder›anemia
  • Anemia›amino-acid-deficiency
  • Anemia›orotaciduric(congenital) (hereditary)
  • Anemia›protein-deficiency
  • Orotaciduria, oroticaciduria›anemia
  • Aciduria›orotic›anemia
  • Anemia›deficiency›amino-acid
  • Anemia›deficiency›protein
  • Anemia›megaloblastic›orotic aciduria
  • Deficiency, deficient›protein›anemia
  • Anemia›due to›deficiency›amino-acid
  • Anemia›due to›deficiency›protein

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under D53

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.