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C49.3

C49.3Malignant neoplasm of connective and soft tissue of thorax

Billable / specific codeICD-10-CM

C49.3 is a billable, specific ICD-10-CM code for malignant neoplasm of connective and soft tissue of thorax. It is valid for submission on a claim.

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • malignant neoplasm of breast (C50.-)
  • malignant neoplasm of heart (C38.0)
  • malignant neoplasm of mediastinum (C38.1-C38.3)
  • malignant neoplasm of thymus (C37)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Malignant neoplasm of axilla
  • Malignant neoplasm of diaphragm
  • Malignant neoplasm of great vessels

Other codes that can never be billed with C49.3

These codes carry an Excludes1 note pointing at C49.3. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading C49.3 alone.

  • C38.0Malignant neoplasm of heart

Risk adjustment

C49.3 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 21 Lymphoma and Other Cancers0.671 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

C49.3 is named in 74 Medicare coverage policies 74 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A52370Billing and Coding: Bevacizumab and biosimilars
  • A52450Billing and Coding: Paclitaxel (e.g., Taxol®/Abraxane ™)
  • A52479Oral Anticancer Drugs - Policy Article
  • A52479Oral Anticancer Drugs - Policy Article

Related codes at this level

Codes that share C49. If C49.3 is not quite right, the correct code is usually one of these.

Questions about C49.3

Is C49.3 a billable ICD-10-CM code?
Yes. C49.3 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does C49.3 sit in the tabular list?
Neoplasms (C00-D49), in the block Malignant neoplasms of mesothelial and soft tissue (C45-C49).
What cannot be coded together with C49.3?
C49.3 carries an Excludes1 note, which means the conditions it lists can never be coded together with it on the same encounter.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.