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C45.9

C45.9Mesothelioma, unspecified

Billable / specific codeICD-10-CM

C45.9 is a billable, specific ICD-10-CM code for mesothelioma, unspecified. It is valid for submission on a claim.

Risk adjustment

C45.9 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 19 Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers1.798 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

C45.9 is named in 48 Medicare coverage policies 48 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A52450Billing and Coding: Paclitaxel (e.g., Taxol®/Abraxane ™)
  • A52479Oral Anticancer Drugs - Policy Article
  • A52479Oral Anticancer Drugs - Policy Article
  • A52479Oral Anticancer Drugs - Policy Article

How C45.9 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to C45.9.

  • Mesothelioma(malignant)
  • Mesotheliomabiphasic
  • Mesotheliomaepithelioid
  • Mesotheliomafibrous
  • Mesotheliomasite classificationunspecified

Related codes at this level

Codes that share C45. If C45.9 is not quite right, the correct code is usually one of these.

Questions about C45.9

Is C45.9 a billable ICD-10-CM code?
Yes. C45.9 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does C45.9 sit in the tabular list?
Neoplasms (C00-D49), in the block Malignant neoplasms of mesothelial and soft tissue (C45-C49).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.