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C22.9

C22.9: Malignant neoplasm of liver, not specified as primary or secondary

Billable / specific codeICD-10-CM

C22.9 is a billable, specific ICD-10-CM code for malignant neoplasm of liver, not specified as primary or secondary. It is valid for submission on a claim.

Check C22.9 with the rest of the claim: free scrubber

Excludes1 inherited from the categories above C22.9

A category’s note binds every code beneath it.

Written on C22: Malignant neoplasm of liver and intrahepatic bile ducts

  • malignant neoplasm of biliary tract NOS (C24.9)
  • secondary malignant neoplasm of liver and intrahepatic bile duct (C78.7)

Risk adjustment

C22.9 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 20 Lung and Other Severe Cancers1.136 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score. Look up the whole chart to see which of its HCCs the hierarchy would zero.

Medicare coverage

C22.9 is named in 63 Medicare coverage policies: 63 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A52370Billing and Coding: Bevacizumab and biosimilars
  • A52479Oral Anticancer Drugs - Policy Article
  • A52480Oral Antiemetic Drugs (Replacement for Intravenous Antiemetics) - Policy Article
  • A52986Billing and Coding: Biomarkers for Oncology

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under C22

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.