C9452 — Injection, ceftolozane 50 mg and tazobactam 25 mg
C9452 is a HCPCS Level II code for injection, ceftolozane 50 mg and tazobactam 25 mg. It belongs to the Outpatient Prospective Payment System section. It was terminated on December 31, 2015 and is not valid on new claims.
This code has been terminated
CMS terminated C9452 on December 31, 2015. It stays in the file as history — a claim you are auditing from before that date may legitimately carry it — but it must not appear on a new claim. The adjacent codes below are the usual place to look for its replacement.
Medicare coverage: Special coverage instructions apply
There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
The CMS record for C9452
- Long descriptor
- Injection, ceftolozane 50 mg and tazobactam 25 mg
- Short descriptor
- Inj, ceftolozane/tazobactam
- Added
- April 1, 2015
- Terminated
- December 31, 2015
- BETOS
- O1E
- Pricing indicator
- 53 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
When CMS retired it.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Statute.
Codes adjacent to C9452
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If C9452 is not quite right, the correct code is very often within a few positions of it.
- C9444Injection, oritavancin, 10 mgterminated
- C9445Injection, c-1 esterase inhibitor (recombinant), ruconest, 10 unitsterminated
- C9446Injection, tedizolid phosphate, 1 mgterminated
- C9447Injection, phenylephrine and ketorolac, 4 ml vialterminated
- C9448Netupitant 300 mg and palonosetron 0.5 mg, oralterminated
- C9449Injection, blinatumomab, 1 mcgterminated
- C9450Injection, fluocinolone acetonide intravitreal implant, 0.01 mgterminated
- C9451Injection, peramivir, 1 mgterminated
- C9453Injection, nivolumab, 1 mgterminated
- C9454Injection, pasireotide long acting, 1 mgterminated
- C9455Injection, siltuximab, 10 mgterminated
- C9456Injection, isavuconazonium sulfate, 1 mgterminated
- C9457Injection, sulfur hexafluoride lipid microsphere, per mlterminated
- C9458Florbetaben f18, diagnostic, per study dose, up to 8.1 millicuriesterminated
- C9459Flutemetamol f18, diagnostic, per study dose, up to 5 millicuriesterminated
- C9460Injection, cangrelor, 1 mg
Questions about C9452
What is HCPCS code C9452?
C9452 is a HCPCS Level II code for injection, ceftolozane 50 mg and tazobactam 25 mg. It sits in the Outpatient Prospective Payment System section.
Does Medicare cover C9452?
The CMS HCPCS file marks C9452 as "Special coverage instructions apply". There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
Is C9452 still valid?
No. C9452 was terminated on December 31, 2015 and should not be used on new claims.