C9457 — Injection, sulfur hexafluoride lipid microsphere, per ml
C9457 is a HCPCS Level II code for injection, sulfur hexafluoride lipid microsphere, per ml. It belongs to the Outpatient Prospective Payment System section. It was terminated on December 31, 2015 and is not valid on new claims.
This code has been terminated
CMS terminated C9457 on December 31, 2015. It stays in the file as history — a claim you are auditing from before that date may legitimately carry it — but it must not appear on a new claim. The adjacent codes below are the usual place to look for its replacement.
Medicare coverage: Special coverage instructions apply
There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
The CMS record for C9457
- Long descriptor
- Injection, sulfur hexafluoride lipid microsphere, per ml
- Short descriptor
- Lumason contrast agent
- Added
- October 1, 2015
- Terminated
- December 31, 2015
- BETOS
- O1E
- Pricing indicator
- 53 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
When CMS retired it.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Statute.
Codes adjacent to C9457
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If C9457 is not quite right, the correct code is very often within a few positions of it.
- C9449Injection, blinatumomab, 1 mcgterminated
- C9450Injection, fluocinolone acetonide intravitreal implant, 0.01 mgterminated
- C9451Injection, peramivir, 1 mgterminated
- C9452Injection, ceftolozane 50 mg and tazobactam 25 mgterminated
- C9453Injection, nivolumab, 1 mgterminated
- C9454Injection, pasireotide long acting, 1 mgterminated
- C9455Injection, siltuximab, 10 mgterminated
- C9456Injection, isavuconazonium sulfate, 1 mgterminated
- C9458Florbetaben f18, diagnostic, per study dose, up to 8.1 millicuriesterminated
- C9459Flutemetamol f18, diagnostic, per study dose, up to 5 millicuriesterminated
- C9460Injection, cangrelor, 1 mg
- C9461Choline c 11, diagnostic, per study doseterminated
- C9462Injection, delafloxacin, 1 mg
- C9463Injection, aprepitant, 1 mgterminated
- C9464Injection, rolapitant, 0.5 mgterminated
- C9465Hyaluronan or derivative, durolane, for intra-articular injection, per doseterminated
Questions about C9457
What is HCPCS code C9457?
C9457 is a HCPCS Level II code for injection, sulfur hexafluoride lipid microsphere, per ml. It sits in the Outpatient Prospective Payment System section.
Does Medicare cover C9457?
The CMS HCPCS file marks C9457 as "Special coverage instructions apply". There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
Is C9457 still valid?
No. C9457 was terminated on December 31, 2015 and should not be used on new claims.