MCMedicalCodingSoftware
Z92.22

Z92.22: Personal history of monoclonal drug therapy

Billable / specific codeICD-10-CMPOA exempt

Z92.22 is a billable, specific ICD-10-CM code for personal history of monoclonal drug therapy. It is valid for submission on a claim.

Check Z92.22 with the rest of the claim: free scrubber

Excludes2: not included here, but may coexist

The excluded condition is not part of this code, but a patient can have both. You may code both.

  • personal history of immune checkpoint inhibitor therapy (Z92.26)

Excludes2 inherited from the categories above Z92.22

Not part of this code, but both may be coded when both are present.

Written on Z92.2: Personal history of drug therapy

  • long term (current) drug therapy (Z79.-)

Written on Z92: Personal history of medical treatment

  • postprocedural states (Z98.-)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

Z92.22 is named in 3 Medicare coverage policies: 3 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A56907Billing and Coding: Bisphosphonate Drug Therapy
  • A57189Billing and Coding: Serum Magnesium
  • A59561Billing and Coding: Bisphosphonate Drug Therapy

Alphabetic index entries that lead here

  • History›personal›drug therapy›monoclonal drug

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under Z92.2

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.