MCMedicalCodingSoftware
Z15.81

Z15.81: Genetic susceptibility to multiple endocrine neoplasia [MEN]

Billable / specific codeICD-10-CMPOA exempt

Z15.81 is a billable, specific ICD-10-CM code for genetic susceptibility to multiple endocrine neoplasia [men]. It is valid for submission on a claim.

Check Z15.81 with the rest of the claim: free scrubber

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • multiple endocrine neoplasia [MEN] syndromes (E31.2-)

Excludes1 inherited from the categories above Z15.81

A category’s note binds every code beneath it.

Written on Z15: Genetic susceptibility to disease

  • chromosomal anomalies (Q90-Q99)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Alphabetic index entries that lead here

  • Susceptibility to disease, genetic›multiple endocrine neoplasia
  • Genetic›susceptibility to disease NEC›multiple endocrine neoplasia

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under Z15.8

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.