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T45.8X5D

T45.8X5D — Adverse effect of other primarily systemic and hematological agents, subsequent encounter

Billable / specific codeICD-10-CMPOA exempt

T45.8X5D is a billable, specific ICD-10-CM code for adverse effect of other primarily systemic and hematological agents, subsequent encounter. It is valid for submission on a claim.

7th character "D" — subsequent encounter

The appropriate 7th character is to be added to each code from category T45

A
initial encounter
D
subsequent encounter
S
sequela

Excludes2 inherited from the categories above T45.8X5D

Also inherited, and the opposite of Excludes1: these conditions are not part of T45.8X5D, but a patient can have both, so you may code both.

Written on T45.8 — Poisoning by, adverse effect of and underdosing of other primarily systemic and hematological agents

  • poisoning by, adverse effect of and underdosing of immunoglobulin (T50.Z1)
  • poisoning by, adverse effect of and underdosing of iron (T45.4)
  • transfusion reactions (T80.-)

Risk adjustment

T45.8X5D does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

T45.8X5D is named in 20 Medicare coverage policies — 20 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A56558Billing and Coding: Allergy Testing
  • A56612Billing and Coding: CT of the Head
  • A56625Billing and Coding: Echocardiography
  • A56625Billing and Coding: Echocardiography

Code history

T45.8X5D has not changed since FY2024 — no addition, revision or deletion across the FY2024–FY2027 ICD-10-CM releases.

Related codes at this level

Codes that share T45.8X5. If T45.8X5D is not quite right, the correct code is usually one of these.

Questions about T45.8X5D

Is T45.8X5D a billable ICD-10-CM code?
Yes. T45.8X5D is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does T45.8X5D sit in the tabular list?
Injury, poisoning and certain other consequences of external causes (S00-T88), in the block Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances (T36-T50).
ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.