MCMedicalCodingSoftware
I21

I21: Acute myocardial infarction

Non-billable headerICD-10-CM

I21 is a non-billable header ICD-10-CM code for acute myocardial infarction. It cannot be billed on its own: choose one of the more specific child codes below.

Excludes2: not included here, but may coexist

The excluded condition is not part of this code, but a patient can have both. You may code both.

  • old myocardial infarction (I25.2)
  • postmyocardial infarction syndrome (I24.1)
  • subsequent type 1 myocardial infarction (I22.-)

Use additional code

Add a secondary code to capture the detail described below.

  • code, if applicable, to identify:
  • exposure to environmental tobacco smoke (Z77.22)
  • history of tobacco dependence (Z87.891)
  • occupational exposure to environmental tobacco smoke (Z57.31)
  • status post administration of tPA (rtPA) in a different facility within the last 24 hours prior to admission to current facility (Z92.82)
  • tobacco dependence (F17.-)
  • tobacco use (Z72.0)

Includes

Conditions this code covers.

  • cardiac infarction
  • coronary (artery) embolism
  • coronary (artery) occlusion
  • coronary (artery) rupture
  • coronary (artery) thrombosis
  • infarction of heart, myocardium, or ventricle
  • myocardial infarction specified as acute or with a stated duration of 4 weeks (28 days) or less from onset

Other codes that can never be billed with I21

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • I22Subsequent ST elevation (STEMI) and non-ST elevation (NSTEMI) myocardial infarction
  • I24.8Other forms of acute ischemic heart disease
  • I25.82Chronic total occlusion of coronary artery
  • I5ANon-ischemic myocardial injury (non-traumatic)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Code history

Unchanged in every release from FY2024 to FY2027.

Code to one of these instead I21

8 child codes. Green means billable.

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.