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G90.81

G90.81: Serotonin syndrome

Billable / specific codeICD-10-CM

G90.81 is a billable, specific ICD-10-CM code for serotonin syndrome. It is valid for submission on a claim.

Check G90.81 with the rest of the claim: free scrubber

Code first

The underlying condition must be sequenced before this code.

  • poisoning due to drug or toxin, such as:
  • linezolid (T36.8X- with sixth character 1-4)
  • monoamine oxidase inhibitors (T43.1X with sixth character 1-4)
  • selective serotonin and norepinephrine reuptake inhibitors [SSNRI] (T43.21 with sixth character 1-4)
  • selective serotonin reuptake inhibitors [SSRI] (T43.22 with sixth character 1-4)

Use additional code

Add a secondary code to capture the detail described below.

  • code for adverse effect, if applicable, to identify drug, such as:
  • linezolid (T36.8X5)
  • monoamine oxidase inhibitors (T43.1X5)
  • selective serotonin and norepinephrine reuptake inhibitors [SSNRI] (T43.215)
  • selective serotonin reuptake inhibitors [SSRI] (T43.225)
  • code, if applicable, to identify:
  • disseminated intravascular coagulation (D65)
  • hypertensive crisis (I16.-)
  • metabolic acidosis (E87.2-)
  • shock, not elsewhere classified (R57.-)
  • toxic encephalopathy (G92.-)
  • ventricular tachycardia (I47.2-)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Serotonin toxicity

Excludes1 inherited from the categories above G90.81

A category’s note binds every code beneath it.

Written on G90: Disorders of autonomic nervous system

  • dysfunction of the autonomic nervous system due to alcohol (G31.2)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

G90.81 is named in 3 Medicare coverage policies: 3 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A56612Billing and Coding: CT of the Head
  • A56771Billing and Coding: Special Electroencephalography
  • A57668Billing and Coding: Nerve Conduction Studies and Electromyography

Alphabetic index entries that lead here

  • Syndrome›serotonin

Code history

  • addedFY2024-FY2027

    Serotonin syndrome

Other codes under G90.8

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.