MCMedicalCodingSoftware
E77.0

E77.0: Defects in post-translational modification of lysosomal enzymes

Billable / specific codeICD-10-CM

E77.0 is a billable, specific ICD-10-CM code for defects in post-translational modification of lysosomal enzymes. It is valid for submission on a claim.

Check E77.0 with the rest of the claim: free scrubber

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Mucolipidosis II [I-cell disease]
  • Mucolipidosis III [pseudo-Hurler polydystrophy]

Other codes that can never be billed with E77.0

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • E75Disorders of sphingolipid metabolism and other lipid storage disorders

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

E77.0 is named in 10 Medicare coverage policies: 10 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A52996Billing and Coding: Routine Foot Care
  • A56232Billing and Coding: Foot Care
  • A56943Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment
  • A57037Billing and Coding: MolDX: Biomarkers in Cardiovascular Risk Assessment

Alphabetic index entries that lead here

  • Polydystrophy, pseudo-Hurler
  • Pseudo-Hurler's polydystrophy
  • Defect, defective›lysosomal enzyme, post-translational modification
  • Defect, defective›modification, lysosomal enzymes, post-translational
  • Disease, diseased›I-cell
  • Disease, diseased›pseudo-Hurler's
  • Mucolipidosis›II, III

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under E77

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.