MCMedicalCodingSoftware
E53.1

E53.1: Pyridoxine deficiency

Billable / specific codeICD-10-CM

E53.1 is a billable, specific ICD-10-CM code for pyridoxine deficiency. It is valid for submission on a claim.

Check E53.1 with the rest of the claim: free scrubber

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • pyridoxine-responsive sideroblastic anemia (D64.3)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Vitamin B6 deficiency

Excludes1 inherited from the categories above E53.1

A category’s note binds every code beneath it.

Written on E53: Deficiency of other B group vitamins

  • sequelae of vitamin B deficiency (E64.8)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

E53.1 is named in 8 Medicare coverage policies: 8 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A52996Billing and Coding: Routine Foot Care
  • A54095Billing and Coding: Nerve Conduction Studies and Electromyography
  • A56416Billing and Coding: Assays for Vitamins and Metabolic Function
  • A57123Billing and Coding: Nerve Conduction Studies and Electromyography

Alphabetic index entries that lead here

  • Avitaminosis›B6
  • Deficiency, deficient›pyracin(alpha) (beta)
  • Deficiency, deficient›pyridoxal
  • Deficiency, deficient›pyridoxamine
  • Deficiency, deficient›pyridoxine(derivatives)
  • Dependence›vitamin B6
  • Syndrome›vitamin B6 deficiency
  • Deficiency, deficient›vitamin NOS›B6
  • Polyneuropathy›in›deficiency›vitamin B6

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under E53

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.