Is E53.1 a billable ICD-10-CM code?

Yes. E53.1 is a billable, specific ICD-10-CM code and is valid for submission on a claim.

Where does E53.1 sit in the tabular list?

Endocrine, nutritional and metabolic diseases (E00-E89), in the block Other nutritional deficiencies (E50-E64).

What cannot be coded together with E53.1?

E53.1 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above E53.1 (E53) and apply to it just the same.

E53.1

E53.1 — Pyridoxine deficiency

Billable / specific codeICD-10-CM

E53.1 is a billable, specific ICD-10-CM code for pyridoxine deficiency. It is valid for submission on a claim.

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

pyridoxine-responsive sideroblastic anemia (D64.3)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

Vitamin B6 deficiency

Excludes1 inherited from the categories above E53.1

These are not written on E53.1, but they bind it: a note on a category applies to every code beneath it. Billing E53.1 with anything listed here is a denial.

Written on E53 — Deficiency of other B group vitamins

sequelae of vitamin B deficiency (E64.8)

Risk adjustment

E53.1 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

E53.1 is named in 11 Medicare coverage policies — 11 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

A52996Billing and Coding: Routine Foot Care
A54095Billing and Coding: Nerve Conduction Studies and Electromyography
A56416Billing and Coding: Assays for Vitamins and Metabolic Function
A57123Billing and Coding: Nerve Conduction Studies and Electromyography

How E53.1 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to E53.1.

Avitaminosis›B6
Deficiency, deficient›pyracin(alpha) (beta)
Deficiency, deficient›pyridoxal
Deficiency, deficient›pyridoxamine
Deficiency, deficient›pyridoxine(derivatives)
Dependence›vitamin B6
Syndrome›vitamin B6 deficiency
Deficiency, deficient›vitamin NOS›B6
Polyneuropathy›in›deficiency›vitamin B6

Code history

E53.1 has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.

Related codes at this level

Codes that share E53. If E53.1 is not quite right, the correct code is usually one of these.

Questions about E53.1

Is E53.1 a billable ICD-10-CM code?: Yes. E53.1 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does E53.1 sit in the tabular list?: Endocrine, nutritional and metabolic diseases (E00-E89), in the block Other nutritional deficiencies (E50-E64).
What cannot be coded together with E53.1?: E53.1 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above E53.1 (E53) and apply to it just the same.