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D68.52

D68.52: Prothrombin gene mutation

Billable / specific codeICD-10-CM

D68.52 is a billable, specific ICD-10-CM code for prothrombin gene mutation. It is valid for submission on a claim.

Check D68.52 with the rest of the claim: free scrubber

Excludes1 inherited from the categories above D68.52

A category’s note binds every code beneath it.

Written on D68.5: Primary thrombophilia

  • antiphospholipid syndrome (D68.61)
  • lupus anticoagulant (D68.62)
  • secondary activated protein C resistance (D68.69)
  • secondary antiphospholipid antibody syndrome (D68.69)
  • secondary lupus anticoagulant with hypercoagulable state (D68.69)
  • secondary systemic lupus erythematosus [SLE] inhibitor with hypercoagulable state (D68.69)
  • systemic lupus erythematosus [SLE] inhibitor finding without diagnosis (R76.0)
  • systemic lupus erythematosus [SLE] inhibitor with hemorrhagic disorder (D68.312)
  • thrombotic thrombocytopenic purpura (M31.19)

Written on D68: Other coagulation defects

  • abnormal coagulation profile NOS (R79.1)

Excludes2 inherited from the categories above D68.52

Not part of this code, but both may be coded when both are present.

Written on D68: Other coagulation defects

  • coagulation defects complicating abortion or ectopic or molar pregnancy (O00-O07, O08.1)
  • coagulation defects complicating pregnancy, childbirth and the puerperium (O45.0, O46.0, O67.0, O72.3)

Other codes that can never be billed with D68.52

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • R79.1Abnormal coagulation profile

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

D68.52 is named in 2 Medicare coverage policies: 2 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A56464Billing and Coding: Flow Cytometry
  • A57594Billing and Coding: Non-Invasive Peripheral Venous Vascular and Hemodialysis Access Studies

Alphabetic index entries that lead here

  • Prothrombin gene mutation
  • Hypercoagulable›prothrombin gene mutation
  • Mutation›prothrombin gene

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under D68.5

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.