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D64.81

D64.81Anemia due to antineoplastic chemotherapy

Billable / specific codeICD-10-CM

D64.81 is a billable, specific ICD-10-CM code for anemia due to antineoplastic chemotherapy. It is valid for submission on a claim.

Excludes2 — not included here, but may coexist

The excluded condition is not part of this code, but a patient can have both. You may code both.

  • anemia in neoplastic disease (D63.0)
  • aplastic anemia due to antineoplastic chemotherapy (D61.1)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Antineoplastic chemotherapy induced anemia

Excludes1 inherited from the categories above D64.81

These are not written on D64.81, but they bind it: a note on a category applies to every code beneath it. Billing D64.81 with anything listed here is a denial.

Written on D64 Other anemias

  • refractory anemia (D46.-)
  • refractory anemia with excess blasts in transformation [RAEB T] (C92.0-)

Risk adjustment

D64.81 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

D64.81 is named in 11 Medicare coverage policies 11 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A56464Billing and Coding: Flow Cytometry
  • A56795Billing and Coding: Erythropoiesis Stimulating Agents (ESAs)
  • A58710Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing
  • A58710Billing and Coding: MolDX: Molecular Syndromic Panels for Infectious Disease Pathogen Identification Testing

How D64.81 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to D64.81.

  • Anemiadue toantineoplastic chemotherapy
  • Anemiadue tochemotherapy, antineoplastic

The condition this code belongs to

Every code for the condition on one page, which one applies when, and the mistake coders make with it.

Code history

D64.81 has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.

Related codes at this level

Codes that share D64.8. If D64.81 is not quite right, the correct code is usually one of these.

Questions about D64.81

Is D64.81 a billable ICD-10-CM code?
Yes. D64.81 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does D64.81 sit in the tabular list?
Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism (D50-D89), in the block Aplastic and other anemias and other bone marrow failure syndromes (D60-D64).
What cannot be coded together with D64.81?
D64.81 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above D64.81 (D64) and apply to it just the same.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.