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C96.0

C96.0Multifocal and multisystemic (disseminated) Langerhans-cell histiocytosis

Billable / specific codeICD-10-CM

C96.0 is a billable, specific ICD-10-CM code for multifocal and multisystemic (disseminated) langerhans-cell histiocytosis. It is valid for submission on a claim.

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • adult pulmonary Langerhans cell histiocytosis (J84.82)
  • multifocal and unisystemic Langerhans-cell histiocytosis (C96.5)
  • unifocal Langerhans-cell histiocytosis (C96.6)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Histiocytosis X, multisystemic
  • Letterer-Siwe disease

Other codes that can never be billed with C96.0

These codes carry an Excludes1 note pointing at C96.0. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading C96.0 alone.

  • C96.5Multifocal and unisystemic Langerhans-cell histiocytosis
  • C96.6Unifocal Langerhans-cell histiocytosis
  • D76Other specified diseases with participation of lymphoreticular and reticulohistiocytic tissue

Risk adjustment

C96.0 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 21 Lymphoma and Other Cancers0.671 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

C96.0 is named in 42 Medicare coverage policies 42 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A52479Oral Anticancer Drugs - Policy Article
  • A52479Oral Anticancer Drugs - Policy Article
  • A52479Oral Anticancer Drugs - Policy Article
  • A52479Oral Anticancer Drugs - Policy Article

How C96.0 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to C96.0.

  • Letterer-Siwe's disease
  • Histiocytosisacute differentiated progressive
  • Reticuloendotheliosisacute infantile
  • Reticuloendotheliosisnonlipid
  • Reticulosisacute of infancy
  • HistiocytosisX NECacute(progressive)
  • HistiocytosisX NECmultisystemic
  • HistiocytosisLangerhans' cell NECmultifocal Xmultisystemic(disseminated)

Related codes at this level

Codes that share C96. If C96.0 is not quite right, the correct code is usually one of these.

Questions about C96.0

Is C96.0 a billable ICD-10-CM code?
Yes. C96.0 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does C96.0 sit in the tabular list?
Neoplasms (C00-D49), in the block Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96).
What cannot be coded together with C96.0?
C96.0 carries an Excludes1 note, which means the conditions it lists can never be coded together with it on the same encounter.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.