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C21.1

C21.1Malignant neoplasm of anal canal

Billable / specific codeICD-10-CM

C21.1 is a billable, specific ICD-10-CM code for malignant neoplasm of anal canal. It is valid for submission on a claim.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Malignant neoplasm of anal sphincter

Risk adjustment

C21.1 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 22 Bladder, Colorectal, and Other Cancers0.363 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

C21.1 is named in 103 Medicare coverage policies 103 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A52450Billing and Coding: Paclitaxel (e.g., Taxol®/Abraxane ™)
  • A52450Billing and Coding: Paclitaxel (e.g., Taxol®/Abraxane ™)
  • A52479Oral Anticancer Drugs - Policy Article
  • A52479Oral Anticancer Drugs - Policy Article

Related codes at this level

Codes that share C21. If C21.1 is not quite right, the correct code is usually one of these.

Questions about C21.1

Is C21.1 a billable ICD-10-CM code?
Yes. C21.1 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does C21.1 sit in the tabular list?
Neoplasms (C00-D49), in the block Malignant neoplasms of digestive organs (C15-C26).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.