S5522 — Home infusion therapy, insertion of peripherally inserted central venous catheter (picc), nursing services only (no supplies or catheter included)
S5522 is a HCPCS Level II code for home infusion therapy, insertion of peripherally inserted central venous catheter (picc), nursing services only (no supplies or catheter included). It belongs to the Temporary National Codes (Non-Medicare) section. Medicare does not pay it — see the coverage note below before you bill it.
Medicare coverage: Not payable by Medicare
Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusI
Not valid for Medicare purposes. Medicare uses another code.
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
The CMS record for S5522
- Long descriptor
- Home infusion therapy, insertion of peripherally inserted central venous catheter (picc), nursing services only (no supplies or catheter included)
- Short descriptor
- Hit picc insert no supp
- Added
- January 1, 2002
- BETOS
- Z2
- Pricing indicator
- 00 — Not priced by Part B
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Service not separately priced by Part B — not covered, bundled into another service, or used by Part A only.
Codes adjacent to S5522
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If S5522 is not quite right, the correct code is very often within a few positions of it.
- S5497Home infusion therapy, catheter care / maintenance, not otherwise classified; includes administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem
- S5498Home infusion therapy, catheter care / maintenance, simple (single lumen), includes administrative services, professional pharmacy services, care coordination and all necessary supplies and equipment, (drugs and nursing visits coded separately), per diem
- S5501Home infusion therapy, catheter care / maintenance, complex (more than one lumen), includes administrative services, professional pharmacy services, care coordination, and all necessary supplies and equipment (drugs and nursing visits coded separately), per diem
- S5502Home infusion therapy, catheter care / maintenance, implanted access device, includes administrative services, professional pharmacy services, care coordination and all necessary supplies and equipment, (drugs and nursing visits coded separately), per diem (use this code for interim maintenance of vascular access not currently in use)
- S5517Home infusion therapy, all supplies necessary for restoration of catheter patency or declotting
- S5518Home infusion therapy, all supplies necessary for catheter repair
- S5520Home infusion therapy, all supplies (including catheter) necessary for a peripherally inserted central venous catheter (picc) line insertion
- S5521Home infusion therapy, all supplies (including catheter) necessary for a midline catheter insertion
- S5523Home infusion therapy, insertion of midline venous catheter, nursing services only (no supplies or catheter included)
- S5550Insulin, rapid onset, 5 units
- S5551Insulin, most rapid onset (lispro or aspart); 5 units
- S5552Insulin, intermediate acting (nph or lente); 5 units
- S5553Insulin, long acting; 5 units
- S5560Insulin delivery device, reusable pen; 1.5 ml size
- S5561Insulin delivery device, reusable pen; 3 ml size
- S5565Insulin cartridge for use in insulin delivery device other than pump; 150 units
Questions about S5522
What is HCPCS code S5522?
S5522 is a HCPCS Level II code for home infusion therapy, insertion of peripherally inserted central venous catheter (picc), nursing services only (no supplies or catheter included). It sits in the Temporary National Codes (Non-Medicare) section.
Does Medicare cover S5522?
The CMS HCPCS file marks S5522 as "Not payable by Medicare". Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
How is S5522 paid under the physician fee schedule?
S5522 carries PFS status code I. Not valid for Medicare purposes. Medicare uses another code.