S3840 — Dna analysis for germline mutations of the ret proto-oncogene for susceptibility to multiple endocrine neoplasia type 2
S3840 is a HCPCS Level II code for dna analysis for germline mutations of the ret proto-oncogene for susceptibility to multiple endocrine neoplasia type 2. It belongs to the Temporary National Codes (Non-Medicare) section. Medicare does not pay it — see the coverage note below before you bill it.
Medicare coverage: Not payable by Medicare
Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusI
Not valid for Medicare purposes. Medicare uses another code.
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
The CMS record for S3840
- Long descriptor
- Dna analysis for germline mutations of the ret proto-oncogene for susceptibility to multiple endocrine neoplasia type 2
- Short descriptor
- Dna analysis ret-oncogene
- Added
- July 1, 2003
- BETOS
- Z2
- Pricing indicator
- 00 — Not priced by Part B
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Service not separately priced by Part B — not covered, bundled into another service, or used by Part A only.
Codes adjacent to S3840
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If S3840 is not quite right, the correct code is very often within a few positions of it.
- S3645Hiv-1 antibody testing of oral mucosal transudate
- S3650Saliva test, hormone level; during menopause
- S3652Saliva test, hormone level; to assess preterm labor risk
- S3655Antisperm antibodies test (immunobead)
- S3708Gastrointestinal fat absorption study
- S3721Prostate cancer antigen 3 (pca3) testingterminated
- S3722Dose optimization by area under the curve (auc) analysis, for infusional 5-fluorouracil
- S3800Genetic testing for amyotrophic lateral sclerosis (als)
- S3841Genetic testing for retinoblastoma
- S3842Genetic testing for von hippel-lindau disease
- S3844Dna analysis of the connexin 26 gene (gjb2) for susceptibility to congenital, profound deafness
- S3845Genetic testing for alpha-thalassemia
- S3846Genetic testing for hemoglobin e beta-thalassemia
- S3849Genetic testing for niemann-pick disease
- S3850Genetic testing for sickle cell anemia
- S3852Dna analysis for apoe epsilon 4 allele for susceptibility to alzheimer's disease
Questions about S3840
What is HCPCS code S3840?
S3840 is a HCPCS Level II code for dna analysis for germline mutations of the ret proto-oncogene for susceptibility to multiple endocrine neoplasia type 2. It sits in the Temporary National Codes (Non-Medicare) section.
Does Medicare cover S3840?
The CMS HCPCS file marks S3840 as "Not payable by Medicare". Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
How is S3840 paid under the physician fee schedule?
S3840 carries PFS status code I. Not valid for Medicare purposes. Medicare uses another code.