S2107 — Adoptive immunotherapy i.e. development of specific anti-tumor reactivity (e.g., tumor-infiltrating lymphocyte therapy) per course of treatment
S2107 is a HCPCS Level II code for adoptive immunotherapy i.e. development of specific anti-tumor reactivity (e.g., tumor-infiltrating lymphocyte therapy) per course of treatment. It belongs to the Temporary National Codes (Non-Medicare) section. Medicare does not pay it — see the coverage note below before you bill it.
Medicare coverage: Not payable by Medicare
Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusI
Not valid for Medicare purposes. Medicare uses another code.
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
The CMS record for S2107
- Long descriptor
- Adoptive immunotherapy i.e. development of specific anti-tumor reactivity (e.g., tumor-infiltrating lymphocyte therapy) per course of treatment
- Short descriptor
- Adoptive immunotherapy
- Added
- April 1, 2002
- BETOS
- Z2
- Pricing indicator
- 00 — Not priced by Part B
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Service not separately priced by Part B — not covered, bundled into another service, or used by Part A only.
Codes adjacent to S2107
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If S2107 is not quite right, the correct code is very often within a few positions of it.
- S2068Breast reconstruction with deep inferior epigastric perforator (diep) flap or superficial inferior epigastric artery (siea) flap, including harvesting of the flap, microvascular transfer, closure of donor site and shaping the flap into a breast, unilateral
- S2070Cystourethroscopy, with ureteroscopy and/or pyeloscopy; with endoscopic laser treatment of ureteral calculi (includes ureteral catheterization)
- S2079Laparoscopic esophagomyotomy (heller type)
- S2080Laser-assisted uvulopalatoplasty (laup)
- S2083Adjustment of gastric band diameter via subcutaneous port by injection or aspiration of saline
- S2095Transcatheter occlusion or embolization for tumor destruction, percutaneous, any method, using yttrium-90 microspheres
- S2102Islet cell tissue transplant from pancreas; allogeneic
- S2103Adrenal tissue transplant to brain
- S2112Arthroscopy, knee, surgical for harvesting of cartilage (chondrocyte cells)
- S2115Osteotomy, periacetabular, with internal fixation
- S2117Arthroereisis, subtalar
- S2118Metal-on-metal total hip resurfacing, including acetabular and femoral components
- S2120Low density lipoprotein (ldl) apheresis using heparin-induced extracorporeal ldl precipitation
- S2140Cord blood harvesting for transplantation, allogeneic
- S2142Cord blood-derived stem-cell transplantation, allogeneic
- S2150Bone marrow or blood-derived stem cells (peripheral or umbilical), allogeneic or autologous, harvesting, transplantation, and related complications; including: pheresis and cell preparation/storage; marrow ablative therapy; drugs, supplies, hospitalization with outpatient follow-up; medical/surgical, diagnostic, emergency, and rehabilitative services; and the number of days of pre-and post-transplant care in the global definition
Questions about S2107
What is HCPCS code S2107?
S2107 is a HCPCS Level II code for adoptive immunotherapy i.e. development of specific anti-tumor reactivity (e.g., tumor-infiltrating lymphocyte therapy) per course of treatment. It sits in the Temporary National Codes (Non-Medicare) section.
Does Medicare cover S2107?
The CMS HCPCS file marks S2107 as "Not payable by Medicare". Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
How is S2107 paid under the physician fee schedule?
S2107 carries PFS status code I. Not valid for Medicare purposes. Medicare uses another code.