S0176 — Hydroxyurea, oral, 500 mg
S0176 is a HCPCS Level II code for hydroxyurea, oral, 500 mg. It belongs to the Temporary National Codes (Non-Medicare) section. Medicare does not pay it — see the coverage note below before you bill it.
Medicare coverage: Not payable by Medicare
Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusI
Not valid for Medicare purposes. Medicare uses another code.
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
The CMS record for S0176
- Long descriptor
- Hydroxyurea, oral, 500 mg
- Short descriptor
- Hydroxyurea 500 mg
- Added
- January 1, 2002
- BETOS
- Z2
- Pricing indicator
- 00 — Not priced by Part B
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Service not separately priced by Part B — not covered, bundled into another service, or used by Part A only.
Codes adjacent to S0176
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If S0176 is not quite right, the correct code is very often within a few positions of it.
- S0164Injection, pantoprazole sodium, 40 mgterminated
- S0166Injection, olanzapine, 2.5 mgterminated
- S0169Calcitrol, 0.25 microgram
- S0170Anastrozole, oral, 1 mg
- S0171Injection, bumetanide, 0.5 mgterminated
- S0172Chlorambucil, oral, 2 mg
- S0174Dolasetron mesylate, oral 50 mg (for circumstances falling under the medicare statute, use q0180)
- S0175Flutamide, oral, 125 mg
- S0177Levamisole hydrochloride, oral, 50 mg
- S0178Lomustine, oral, 10 mg
- S0179Megestrol acetate, oral, 20 mg
- S0182Procarbazine hydrochloride, oral, 50 mg
- S0183Prochlorperazine maleate, oral, 5 mg (for circumstances falling under the medicare statute, use q0164)
- S0187Tamoxifen citrate, oral, 10 mg
- S0189Testosterone pellet, 75 mgterminated
- S0190Mifepristone, oral, 200 mg
Questions about S0176
What is HCPCS code S0176?
S0176 is a HCPCS Level II code for hydroxyurea, oral, 500 mg. It sits in the Temporary National Codes (Non-Medicare) section.
Does Medicare cover S0176?
The CMS HCPCS file marks S0176 as "Not payable by Medicare". Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
How is S0176 paid under the physician fee schedule?
S0176 carries PFS status code I. Not valid for Medicare purposes. Medicare uses another code.