S0166 — Injection, olanzapine, 2.5 mg
S0166 is a HCPCS Level II code for injection, olanzapine, 2.5 mg. It belongs to the Temporary National Codes (Non-Medicare) section. It was terminated on September 30, 2023 and is not valid on new claims.
This code has been terminated
CMS terminated S0166 on September 30, 2023. It stays in the file as history — a claim you are auditing from before that date may legitimately carry it — but it must not appear on a new claim. The adjacent codes below are the usual place to look for its replacement.
Medicare coverage: Not payable by Medicare
Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
The CMS record for S0166
- Long descriptor
- Injection, olanzapine, 2.5 mg
- Short descriptor
- Inj olanzapine 2.5mg
- Added
- October 1, 2004
- Terminated
- September 30, 2023
- BETOS
- Z2
- Pricing indicator
- 00 — Not priced by Part B
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
When CMS retired it.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Service not separately priced by Part B — not covered, bundled into another service, or used by Part A only.
Codes adjacent to S0166
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If S0166 is not quite right, the correct code is very often within a few positions of it.
- S0144Injection, propofol, 10 mgterminated
- S0145Injection, pegylated interferon alfa-2a, 180 mcg per ml
- S0148Injection, pegylated interferon alfa-2b, 10 mcg
- S0155Sterile dilutant for epoprostenol, 50 ml
- S0156Exemestane, 25 mg
- S0157Becaplermin gel 0.01%, 0.5 gm
- S0160Dextroamphetamine sulfate, 5 mg
- S0164Injection, pantoprazole sodium, 40 mgterminated
- S0169Calcitrol, 0.25 microgram
- S0170Anastrozole, oral, 1 mg
- S0171Injection, bumetanide, 0.5 mgterminated
- S0172Chlorambucil, oral, 2 mg
- S0174Dolasetron mesylate, oral 50 mg (for circumstances falling under the medicare statute, use q0180)
- S0175Flutamide, oral, 125 mg
- S0176Hydroxyurea, oral, 500 mg
- S0177Levamisole hydrochloride, oral, 50 mg
Questions about S0166
What is HCPCS code S0166?
S0166 is a HCPCS Level II code for injection, olanzapine, 2.5 mg. It sits in the Temporary National Codes (Non-Medicare) section.
Does Medicare cover S0166?
The CMS HCPCS file marks S0166 as "Not payable by Medicare". Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
Is S0166 still valid?
No. S0166 was terminated on September 30, 2023 and should not be used on new claims.