J0644: Injection, leucovorin calcium (avyxa), 1 mg
J0644 is a HCPCS Level II code for injection, leucovorin calcium (avyxa), 1 mg. It belongs to the Drugs Administered Other Than Oral Method section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Carrier judgment
Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q4-Oct. This states Medicare’s position on the code, not on your particular claim.
The CMS record for J0644
- Long descriptor
- Injection, leucovorin calcium (avyxa), 1 mg
- Short descriptor
- Inj, leucovorin cal (avyxa)
- Added
- October 1, 2026
- BETOS
- O1E
- Pricing indicator
- 51: Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service: CMS's own analytic grouping.
Drugs.
Codes adjacent to J0644
HCPCS has no hierarchy: related items simply sit next to each other in the numbering. If J0644 is not quite right, the correct code is very often within a few positions of it.
- J0630Injection, calcitonin salmon, up to 400 units
- J0636Injection, calcitriol, 0.1 mcg
- J0637Injection, caspofungin acetate, 5 mg
- J0638Injection, canakinumab, 1 mg
- J0640Injection, leucovorin calcium, per 50 mgterminated
- J0641Injection, levoleucovorin, not otherwise specified, 0.5 mg
- J0642Injection, levoleucovorin (khapzory), 0.5 mg
- J0643Injection, leucovorin calcium, not otherwise specified, 1 mg
- J0650Injection, levothyroxine sodium, not otherwise specified, 10 mcg
- J0651Injection, levothyroxine sodium (fresenius kabi), not therapeutically equivalent to j0650, 10 mcg
- J0652Injection, levothyroxine sodium (hikma), not therapeutically equivalent to j0650, 10 mcg
- J0654Injection, liothyronine, 1 mcg
- J0665Injection, bupivicaine, not otherwise specified, 0.5 mg
- J0666Injection, bupivacaine liposome, 1 mg
- J0668Instillation, bupivacaine and meloxicam, 1 mg/0.03 mg
- J0670Injection, mepivacaine hydrochloride, per 10 ml