J0643: Injection, leucovorin calcium, not otherwise specified, 1 mg
J0643 is a HCPCS Level II code for injection, leucovorin calcium, not otherwise specified, 1 mg. It belongs to the Drugs Administered Other Than Oral Method section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Special coverage instructions apply
There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q4-Oct. This states Medicare’s position on the code, not on your particular claim.
The CMS record for J0643
- Long descriptor
- Injection, leucovorin calcium, not otherwise specified, 1 mg
- Short descriptor
- Inj leucovorin calcium 1 mg
- Added
- October 1, 2026
- BETOS
- O1E
- Pricing indicator
- 51: Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service: CMS's own analytic grouping.
Drugs.
Codes adjacent to J0643
HCPCS has no hierarchy: related items simply sit next to each other in the numbering. If J0643 is not quite right, the correct code is very often within a few positions of it.
- J0620Injection, calcium glycerophosphate and calcium lactate, per 10 ml
- J0630Injection, calcitonin salmon, up to 400 units
- J0636Injection, calcitriol, 0.1 mcg
- J0637Injection, caspofungin acetate, 5 mg
- J0638Injection, canakinumab, 1 mg
- J0640Injection, leucovorin calcium, per 50 mgterminated
- J0641Injection, levoleucovorin, not otherwise specified, 0.5 mg
- J0642Injection, levoleucovorin (khapzory), 0.5 mg
- J0644Injection, leucovorin calcium (avyxa), 1 mg
- J0650Injection, levothyroxine sodium, not otherwise specified, 10 mcg
- J0651Injection, levothyroxine sodium (fresenius kabi), not therapeutically equivalent to j0650, 10 mcg
- J0652Injection, levothyroxine sodium (hikma), not therapeutically equivalent to j0650, 10 mcg
- J0654Injection, liothyronine, 1 mcg
- J0665Injection, bupivicaine, not otherwise specified, 0.5 mg
- J0666Injection, bupivacaine liposome, 1 mg
- J0668Instillation, bupivacaine and meloxicam, 1 mg/0.03 mg