C9399 — Unclassified drugs or biologicals
C9399 is a HCPCS Level II code for unclassified drugs or biologicals. It belongs to the Outpatient Prospective Payment System section. Whether Medicare pays it depends on the coverage rule below.
Medicare coverage: Special coverage instructions apply
There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
The CMS record for C9399
- Long descriptor
- Unclassified drugs or biologicals
- Short descriptor
- Unclassified drugs or biolog
- Added
- January 1, 2004
- BETOS
- O1E
- Pricing indicator
- 53 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Statute.
Codes adjacent to C9399
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If C9399 is not quite right, the correct code is very often within a few positions of it.
- C9356Tendon, porous matrix of cross-linked collagen and glycosaminoglycan matrix (tenoglide tendon protector sheet), per square centimeter
- C9358Dermal substitute, native, non-denatured collagen, fetal bovine origin (surgimend collagen matrix), per 0.5 square centimeters
- C9359Porous purified collagen matrix bone void filler (integra mozaik osteoconductive scaffold putty, integra os osteoconductive scaffold putty), per 0.5 cc
- C9360Dermal substitute, native, non-denatured collagen, neonatal bovine origin (surgimend collagen matrix), per 0.5 square centimeters
- C9361Collagen matrix nerve wrap (neuromend collagen nerve wrap), per 0.5 centimeter length
- C9362Porous purified collagen matrix bone void filler (integra mozaik osteoconductive scaffold strip), per 0.5 cc
- C9363Skin substitute, integra meshed bilayer wound matrix, per square centimeter
- C9364Porcine implant, permacol, per square centimeter
- C9407Iodine i-131 iobenguane, diagnostic, 1 millicurieterminated
- C9408Iodine i-131 iobenguane, therapeutic, 1 millicurieterminated
- C9441Injection, ferric carboxymaltose, 1 mgterminated
- C9442Injection, belinostat, 10 mgterminated
- C9443Injection, dalbavancin, 10 mgterminated
- C9444Injection, oritavancin, 10 mgterminated
- C9445Injection, c-1 esterase inhibitor (recombinant), ruconest, 10 unitsterminated
- C9446Injection, tedizolid phosphate, 1 mgterminated
Questions about C9399
What is HCPCS code C9399?
C9399 is a HCPCS Level II code for unclassified drugs or biologicals. It sits in the Outpatient Prospective Payment System section.
Does Medicare cover C9399?
The CMS HCPCS file marks C9399 as "Special coverage instructions apply". There are published conditions attached to this code. Check the applicable coverage policy before billing it: the code being valid is not the same as the service being covered.