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Z88.8

Z88.8: Allergy status to other drugs, medicaments and biological substances

Billable / specific codeICD-10-CMPOA exempt

Z88.8 is a billable, specific ICD-10-CM code for allergy status to other drugs, medicaments and biological substances. It is valid for submission on a claim.

Check Z88.8 with the rest of the claim: free scrubber

Excludes2 inherited from the categories above Z88.8

Not part of this code, but both may be coded when both are present.

Written on Z88: Allergy status to drugs, medicaments and biological substances

  • Allergy status, other than to drugs and biological substances (Z91.0-)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

Z88.8 is named in 15 Medicare coverage policies: 15 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A52399Billing and Coding: Denosumab (Prolia®, Xgeva®, Jubbonti®) and biosimilars
  • A56558Billing and Coding: Allergy Testing
  • A56747Billing and Coding: Magnetic Resonance Angiography (MRA)
  • A56805Billing and Coding: Magnetic Resonance Angiography (MRA)

Alphabetic index entries that lead here

  • History›personal›allergy›drugs, medicaments and biological substances›specified NEC
  • History›personal›allergy›medicinal agents›specified NEC

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under Z88

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.