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Z00.6

Z00.6Encounter for examination for normal comparison and control in clinical research program

Billable / specific codeICD-10-CMPOA exempt

Z00.6 is a billable, specific ICD-10-CM code for encounter for examination for normal comparison and control in clinical research program. It is valid for submission on a claim.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Examination of participant or control in clinical research program

Risk adjustment

Z00.6 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

Z00.6 is named in 4 Medicare coverage policies 3 listing it as supporting medical necessity, and 1 listing it as NOT covered. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A53784Billing and Coding: The Routine Costs of Investigational Chemotherapy Drugs Studied In a Qualifying Clinical Trialnot covered
  • A56391Billing and Coding: Implantable Automatic Defibrillators
  • A56391Billing and Coding: Implantable Automatic Defibrillators
  • A59892Billing and Coding: MolDX: Category B IDE Studies

How Z00.6 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to Z00.6.

  • Clinical research investigation(clinical trial) (control subject) (normal comparison) (participant)
  • Admissionclinical research investigation(control) (normal comparison) (participant)
  • Examinationclinical research control or normal comparison(control) (participant)
  • Investigationclinical research subject(control) (normal comparison) (participant)
  • Personadmitted for clinical research, as a control subject(normal comparison) (participant)
  • Admissionexamination at health care facilityclinical research investigation(control) (normal comparison) (participant)
  • Examinationmedicalclinical research, normal subject(control) (participant)
  • Examinationmedicalcontrol subject in clinical research(normal comparison) (participant)

Related codes at this level

Codes that share Z00. If Z00.6 is not quite right, the correct code is usually one of these.

Questions about Z00.6

Is Z00.6 a billable ICD-10-CM code?
Yes. Z00.6 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does Z00.6 sit in the tabular list?
Factors influencing health status and contact with health services (Z00-Z99), in the block Persons encountering health services for examinations (Z00-Z13).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.