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Z00.6

Z00.6: Encounter for examination for normal comparison and control in clinical research program

Billable / specific codeICD-10-CMPOA exempt

Z00.6 is a billable, specific ICD-10-CM code for encounter for examination for normal comparison and control in clinical research program. It is valid for submission on a claim.

Check Z00.6 with the rest of the claim: free scrubber

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Examination of participant or control in clinical research program

Excludes1 inherited from the categories above Z00.6

A category’s note binds every code beneath it.

Written on Z00: Encounter for general examination without complaint, suspected or reported diagnosis

  • encounter for examination for administrative purposes (Z02.-)

Excludes2 inherited from the categories above Z00.6

Not part of this code, but both may be coded when both are present.

Written on Z00: Encounter for general examination without complaint, suspected or reported diagnosis

  • encounter for pre-procedural examinations (Z01.81-)
  • special screening examinations (Z11-Z13)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

Z00.6 is named in 3 Medicare coverage policies: 2 listing it as supporting medical necessity, and 1 listing it as NOT covered. Which one applies depends on your Medicare contractor.

  • A53784Billing and Coding: The Routine Costs of Investigational Chemotherapy Drugs Studied In a Qualifying Clinical Trialnot covered
  • A56391Billing and Coding: Implantable Automatic Defibrillators
  • A59892Billing and Coding: MolDX: Category B IDE Studies

Alphabetic index entries that lead here

  • Clinical research investigation(clinical trial) (control subject) (normal comparison) (participant)
  • Admission›clinical research investigation(control) (normal comparison) (participant)
  • Examination›clinical research control or normal comparison(control) (participant)
  • Investigation›clinical research subject(control) (normal comparison) (participant)
  • Person›admitted for clinical research, as a control subject(normal comparison) (participant)
  • Admission›examination at health care facility›clinical research investigation(control) (normal comparison) (participant)
  • Examination›medical›clinical research, normal subject(control) (participant)
  • Examination›medical›control subject in clinical research(normal comparison) (participant)

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under Z00

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.