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T80.310

T80.310ABO incompatibility with acute hemolytic transfusion reaction

Non-billable headerICD-10-CM

T80.310 is a non-billable header ICD-10-CM code for abo incompatibility with acute hemolytic transfusion reaction. It cannot be billed on its own: choose one of the more specific child codes below. This code also requires a 7th character before it is complete.

This code requires a 7th character

The appropriate 7th character is to be added to each code from category T80

A
initial encounter
D
subsequent encounter
S
sequela

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • ABO incompatibility with hemolytic transfusion reaction less than 24 hours after transfusion
  • Acute hemolytic transfusion reaction (AHTR) due to ABO incompatibility

Excludes1 inherited from the categories above T80.310

These are not written on T80.310, but they bind it: a note on a category applies to every code beneath it. Billing T80.310 with anything listed here is a denial.

Written on T80.3 ABO incompatibility reaction due to transfusion of blood or blood products

  • minor blood group antigens reactions (Duffy) (E) (K) (Kell) (Kidd) (Lewis) (M) (N) (P) (S) (T80.A-)

Excludes2 inherited from the categories above T80.310

Also inherited, and the opposite of Excludes1: these conditions are not part of T80.310, but a patient can have both, so you may code both.

Written on T80 Complications following infusion, transfusion and therapeutic injection

  • bone marrow transplant rejection (T86.01)
  • febrile nonhemolytic transfusion reaction (R50.84)
  • fluid overload due to transfusion (E87.71)
  • posttransfusion purpura (D69.51)
  • transfusion associated circulatory overload (TACO) (E87.71)
  • transfusion (red blood cell) associated hemochromatosis (E83.111)
  • transfusion related acute lung injury (TRALI) (J95.84)

Risk adjustment

T80.310 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

How T80.310 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to T80.310.

  • Complicationtransfusionincompatibility reactionABOhemolytic transfusion reactionacute(AHTR) (less than 24 hours after transfusion)

Code history

T80.310 has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.

Code to one of these instead T80.310

3 child codes. Green means billable.

Related codes at this level

Codes that share T80.31. If T80.310 is not quite right, the correct code is usually one of these.

Questions about T80.310

Is T80.310 a billable ICD-10-CM code?
No. T80.310 is a non-billable header code. Code to a higher level of specificity using one of its child codes.
Where does T80.310 sit in the tabular list?
Injury, poisoning and certain other consequences of external causes (S00-T88), in the block Complications of surgical and medical care, not elsewhere classified (T80-T88).
What cannot be coded together with T80.310?
T80.310 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above T80.310 (T80.3) and apply to it just the same.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.