MCMCB Pro
R74.8

R74.8Abnormal levels of other serum enzymes

Billable / specific codeICD-10-CM

R74.8 is a billable, specific ICD-10-CM code for abnormal levels of other serum enzymes. It is valid for submission on a claim.

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Abnormal level of acid phosphatase
  • Abnormal level of alkaline phosphatase
  • Abnormal level of amylase
  • Abnormal level of lipase [triacylglycerol lipase]

Risk adjustment

R74.8 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

R74.8 is named in 5 Medicare coverage policies 5 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A55336Billing and Coding: Retroperitoneal Ultrasound
  • A56416Billing and Coding: Assays for Vitamins and Metabolic Function
  • A56421Billing and Coding: CT of the Abdomen and Pelvis
  • A56767Billing and Coding: Heavy Metal Testing

How R74.8 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to R74.8.

  • Abnormal, abnormality, abnormalitiesserum levelacid phosphatase
  • Abnormal, abnormality, abnormalitiesserum levelalkaline phosphatase
  • Abnormal, abnormality, abnormalitiesserum levelamylase
  • Abnormal, abnormality, abnormalitiesserum levellipase
  • Abnormal, abnormality, abnormalitiesserum leveltriacylglycerol lipase
  • Abnormal, abnormality, abnormalitiesserum levelenzymesspecified NEC
  • Elevated, elevationliver functiontestalkaline phosphatase
  • Elevated, elevationliver functiontesthepatic enzyme

Related codes at this level

Codes that share R74. If R74.8 is not quite right, the correct code is usually one of these.

Questions about R74.8

Is R74.8 a billable ICD-10-CM code?
Yes. R74.8 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does R74.8 sit in the tabular list?
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99), in the block Abnormal findings on examination of blood, without diagnosis (R70-R79).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.