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R53.0

R53.0Neoplastic (malignant) related fatigue

Billable / specific codeICD-10-CM

R53.0 is a billable, specific ICD-10-CM code for neoplastic (malignant) related fatigue. It is valid for submission on a claim.

Code first

The underlying condition must be sequenced before this code.

  • associated neoplasm

Risk adjustment

R53.0 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

R53.0 is named in 10 Medicare coverage policies 10 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A54969Billing and Coding: Nerve Conduction Studies and Electromyography
  • A56619Billing and Coding: Nerve Conduction Studies and Electromyography
  • A57122Billing and Coding: Parathormone (Parathyroid Hormone)
  • A57189Billing and Coding: Serum Magnesium

How R53.0 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to R53.0.

  • Fatigueneoplasm-related

Related codes at this level

Codes that share R53. If R53.0 is not quite right, the correct code is usually one of these.

Questions about R53.0

Is R53.0 a billable ICD-10-CM code?
Yes. R53.0 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does R53.0 sit in the tabular list?
Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified (R00-R99), in the block General symptoms and signs (R50-R69).
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.