MCMedicalCodingSoftware
O21.1

O21.1: Hyperemesis gravidarum with metabolic disturbance

Billable / specific codeICD-10-CM

O21.1 is a billable, specific ICD-10-CM code for hyperemesis gravidarum with metabolic disturbance. It is valid for submission on a claim.

Check O21.1 with the rest of the claim: free scrubber

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Hyperemesis gravidarum, starting before the end of the 20th week of gestation, with metabolic disturbance such as carbohydrate depletion
  • Hyperemesis gravidarum, starting before the end of the 20th week of gestation, with metabolic disturbance such as dehydration
  • Hyperemesis gravidarum, starting before the end of the 20th week of gestation, with metabolic disturbance such as electrolyte imbalance

Other codes that can never be billed with O21.1

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • E87Other disorders of fluid, electrolyte and acid-base balance
  • R11Nausea and vomiting

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

O21.1 is named in 1 Medicare coverage policy: 1 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A57189Billing and Coding: Serum Magnesium

Alphabetic index entries that lead here

  • Hyperemesis›gravidarum›severe(with metabolic disturbance)
  • Imbalance›electrolyte›due to hyperemesis gravidarum
  • Hyperemesis›gravidarum›with›carbohydrate depletion
  • Hyperemesis›gravidarum›with›dehydration
  • Hyperemesis›gravidarum›with›electrolyte imbalance
  • Hyperemesis›gravidarum›with›metabolic disturbance

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under O21

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.