MCMedicalCodingSoftware
I51.81

I51.81: Takotsubo syndrome

Billable / specific codeICD-10-CM

I51.81 is a billable, specific ICD-10-CM code for takotsubo syndrome. It is valid for submission on a claim.

Check I51.81 with the rest of the claim: free scrubber

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • Reversible left ventricular dysfunction following sudden emotional stress
  • Stress induced cardiomyopathy
  • Takotsubo cardiomyopathy
  • Transient left ventricular apical ballooning syndrome

Excludes2 inherited from the categories above I51.81

Not part of this code, but both may be coded when both are present.

Written on I51: Complications and ill-defined descriptions of heart disease

  • heart disease specified as rheumatic (I00-I09)

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

I51.81 is named in 14 Medicare coverage policies: 14 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A52850Billing and Coding: Cardiac Catheterization and Coronary Angiography
  • A52868Billing and Coding: Transesophageal Echocardiography (TEE)
  • A56423Billing and Coding: Cardiology Non-emergent Outpatient Stress Testing
  • A56476Billing and Coding: Cardiac Radionuclide Imaging

Alphabetic index entries that lead here

  • Cardiomyopathy›stress induced
  • Cardiomyopathy›takotsubo
  • Dysfunction›left ventricular, following sudden emotional stress
  • Syndrome›apical ballooning(transient left ventricular)
  • Syndrome›takotsubo
  • Syndrome›transient left ventricular apical ballooning
  • Dysfunction›ventricular›left, reversible, following sudden emotional stress

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under I51.8

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.