MCMedicalCodingSoftware
G21.0

G21.0: Malignant neuroleptic syndrome

Billable / specific codeICD-10-CM

G21.0 is a billable, specific ICD-10-CM code for malignant neuroleptic syndrome. It is valid for submission on a claim.

Check G21.0 with the rest of the claim: free scrubber

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • neuroleptic induced parkinsonism (G21.11)

Use additional code

Add a secondary code to capture the detail described below.

Excludes1 inherited from the categories above G21.0

A category’s note binds every code beneath it.

Written on G21: Secondary parkinsonism

  • Huntington's disease (G10)
  • neurocognitive disorder with Lewy bodies (G31.83)
  • Shy-Drager syndrome (G90.3)
  • syphilitic Parkinsonism (A52.19)

Other codes that can never be billed with G21.0

Their own Excludes1 notes name this code, so the conflict is not listed above.

  • G20.CParkinsonism, unspecified
  • G21.11Neuroleptic induced parkinsonism

Risk adjustment

No CMS-HCC V28 category: this code does not change a RAF score.

Medicare coverage

G21.0 is named in 12 Medicare coverage policies: 12 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A54111Billing and Coding: Speech Language Pathology (SLP) Services: Communication Disorders
  • A56612Billing and Coding: CT of the Head
  • A56619Billing and Coding: Nerve Conduction Studies and Electromyography
  • A56756Billing and Coding: Home Health - Psychiatric Care

Alphabetic index entries that lead here

  • Syndrome›malignant›neuroleptic

Code history

Unchanged in every release from FY2024 to FY2027.

Other codes under G21

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.