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D48.2

D48.2Neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system

Billable / specific codeICD-10-CM

D48.2 is a billable, specific ICD-10-CM code for neoplasm of uncertain behavior of peripheral nerves and autonomic nervous system. It is valid for submission on a claim.

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • neoplasm of uncertain behavior of peripheral nerves of orbit (D48.7)

Other codes that can never be billed with D48.2

These codes carry an Excludes1 note pointing at D48.2. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading D48.2 alone.

  • D43Neoplasm of uncertain behavior of brain and central nervous system

Risk adjustment

D48.2 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Medicare coverage

D48.2 is named in 22 Medicare coverage policies 22 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A52479Oral Anticancer Drugs - Policy Article
  • A52480Oral Antiemetic Drugs (Replacement for Intravenous Antiemetics) - Policy Article
  • A52986Billing and Coding: Biomarkers for Oncology
  • A56462Billing and Coding: Erythropoiesis Stimulating Agents (ESA)

Related codes at this level

Codes that share D48. If D48.2 is not quite right, the correct code is usually one of these.

Questions about D48.2

Is D48.2 a billable ICD-10-CM code?
Yes. D48.2 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does D48.2 sit in the tabular list?
Neoplasms (C00-D49), in the block Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (D37-D48).
What cannot be coded together with D48.2?
D48.2 carries an Excludes1 note, which means the conditions it lists can never be coded together with it on the same encounter.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.