MCMCB Pro
D45

D45Polycythemia vera

Billable / specific codeICD-10-CM

D45 is a billable, specific ICD-10-CM code for polycythemia vera. It is valid for submission on a claim.

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • familial polycythemia (D75.0)
  • secondary polycythemia (D75.1)

Other codes that can never be billed with D45

These codes carry an Excludes1 note pointing at D45. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading D45 alone.

  • R71Abnormality of red blood cells
  • D75.1Secondary polycythemia

Risk adjustment

D45 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 23 Prostate, Breast, and Other Cancers and Tumors0.186 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

D45 is named in 62 Medicare coverage policies 60 listing it as supporting medical necessity, and 2 listing it as NOT covered. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A56462Billing and Coding: Erythropoiesis Stimulating Agents (ESA)not covered
  • A60435Billing and Coding: Erythropoiesis Stimulating Agents (ESA)not covered
  • A52480Oral Antiemetic Drugs (Replacement for Intravenous Antiemetics) - Policy Article
  • A52986Billing and Coding: Biomarkers for Oncology

How D45 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to D45.

  • Heilmeyer-Schoner disease
  • Erythremiachronic
  • Polycythemiavera

Questions about D45

Is D45 a billable ICD-10-CM code?
Yes. D45 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does D45 sit in the tabular list?
Neoplasms (C00-D49), in the block Neoplasms of uncertain behavior, polycythemia vera and myelodysplastic syndromes (D37-D48).
What cannot be coded together with D45?
D45 carries an Excludes1 note, which means the conditions it lists can never be coded together with it on the same encounter.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.