MCMCB Pro
D21

D21Other benign neoplasms of connective and other soft tissue

Non-billable headerICD-10-CM

D21 is a non-billable header ICD-10-CM code for other benign neoplasms of connective and other soft tissue. It cannot be billed on its own: choose one of the more specific child codes below.

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • benign neoplasm of articular cartilage (D16.-)
  • benign neoplasm of cartilage of larynx (D14.1)
  • benign neoplasm of cartilage of nose (D14.0)
  • benign neoplasm of connective tissue of breast (D24.-)
  • benign neoplasm of peripheral nerves and autonomic nervous system (D36.1-)
  • benign neoplasm of peritoneum (D20.1)
  • benign neoplasm of retroperitoneum (D20.0)
  • benign neoplasm of uterine ligament, any (D28.2)
  • benign neoplasm of vascular tissue (D18.-)
  • hemangioma (D18.0-)
  • lipomatous neoplasm (D17.-)
  • lymphangioma (D18.1)
  • uterine leiomyoma (D25.-)

Includes

Conditions this code covers.

  • benign neoplasm of blood vessel
  • benign neoplasm of bursa
  • benign neoplasm of cartilage
  • benign neoplasm of fascia
  • benign neoplasm of fat
  • benign neoplasm of ligament, except uterine
  • benign neoplasm of lymphatic channel
  • benign neoplasm of muscle
  • benign neoplasm of synovia
  • benign neoplasm of tendon (sheath)
  • benign stromal tumors

Other codes that can never be billed with D21

These codes carry an Excludes1 note pointing at D21. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading D21 alone.

  • D14.0Benign neoplasm of middle ear, nasal cavity and accessory sinuses
  • D15.1Benign neoplasm of heart
  • D16Benign neoplasm of bone and articular cartilage
  • D31Benign neoplasm of eye and adnexa
  • D13Benign neoplasm of other and ill-defined parts of digestive system

Risk adjustment

D21 does not map to an HCC and does not risk-adjust under CMS-HCC V28. That is normal — most ICD-10 codes do not. It still needs to be coded correctly; it just will not move a RAF score.

Code to one of these instead D21

8 child codes. Green means billable.

Questions about D21

Is D21 a billable ICD-10-CM code?
No. D21 is a non-billable header code. Code to a higher level of specificity using one of its child codes.
Where does D21 sit in the tabular list?
Neoplasms (C00-D49), in the block Benign neoplasms, except benign neuroendocrine tumors (D10-D36).
What cannot be coded together with D21?
D21 carries an Excludes1 note, which means the conditions it lists can never be coded together with it on the same encounter.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.