Is C92.21 a billable ICD-10-CM code?

Yes. C92.21 is a billable, specific ICD-10-CM code and is valid for submission on a claim.

Where does C92.21 sit in the tabular list?

Neoplasms (C00-D49), in the block Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96).

What cannot be coded together with C92.21?

C92.21 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above C92.21 (C92) and apply to it just the same.

C92.21

C92.21 — Atypical chronic myeloid leukemia, BCR/ABL-negative, in remission

Billable / specific codeICD-10-CM

C92.21 is a billable, specific ICD-10-CM code for atypical chronic myeloid leukemia, bcr/abl-negative, in remission. It is valid for submission on a claim.

Excludes1 inherited from the categories above C92.21

These are not written on C92.21, but they bind it: a note on a category applies to every code beneath it. Billing C92.21 with anything listed here is a denial.

Written on C92 — Myeloid leukemia

personal history of leukemia (Z85.6)

Other codes that can never be billed with C92.21

These codes carry an Excludes1 note pointing at C92.21. The conflict binds both ways, but ICD-10-CM only writes it down on one side — so you would not find this by reading C92.21 alone.

D72.825Bandemia

Risk adjustment

C92.21 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

HCC 20 Lung and Other Severe Cancers1.136 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

C92.21 is named in 34 Medicare coverage policies — 32 listing it as supporting medical necessity, and 2 listing it as NOT covered. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

A56462Billing and Coding: Erythropoiesis Stimulating Agents (ESA)not covered
A60435Billing and Coding: Erythropoiesis Stimulating Agents (ESA)not covered
A52479Oral Anticancer Drugs - Policy Article
A52479Oral Anticancer Drugs - Policy Article

Code history

C92.21 has not changed since FY2024 — no addition, revision or deletion across the three most recent ICD-10-CM releases.

Related codes at this level

Codes that share C92.2. If C92.21 is not quite right, the correct code is usually one of these.

Questions about C92.21

Is C92.21 a billable ICD-10-CM code?: Yes. C92.21 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does C92.21 sit in the tabular list?: Neoplasms (C00-D49), in the block Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96).
What cannot be coded together with C92.21?: C92.21 carries Excludes1 notes, which means the conditions they list can never be coded together with it on the same encounter. Some are written on the categories above C92.21 (C92) and apply to it just the same.