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C83.390

C83.390Primary central nervous system lymphoma

Billable / specific codeICD-10-CM

C83.390 is a billable, specific ICD-10-CM code for primary central nervous system lymphoma. It is valid for submission on a claim.

Excludes1 — never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • Primary central nervous system lymphoma, Burkitt (C83.79)
  • Primary central nervous system lymphoma, lymphoblastic (C83.59)
  • Primary central nervous system lymphoma, other (C83.89)
  • Primary central nervous system lymphoma, peripheral T-cell (C84.49)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • PCNSL of brain
  • PCNSL of meninges
  • PCNSL of spinal cord
  • PCNSL NOS

Risk adjustment

C83.390 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 20 Lung and Other Severe Cancers1.136 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score.

Medicare coverage

C83.390 is named in 57 Medicare coverage policies 57 listing it as supporting medical necessity. Which of them applies to you depends on your Medicare contractor, and coverage genuinely differs by state.

  • A52370Billing and Coding: Bevacizumab and biosimilars
  • A52479Oral Anticancer Drugs - Policy Article
  • A52479Oral Anticancer Drugs - Policy Article
  • A52479Oral Anticancer Drugs - Policy Article

How C83.390 is indexed

Coders do not find codes by browsing the tabular list — they look them up in the alphabetic index, under the word the physician wrote. These are the index entries that lead here, so you can see which chart wordings map to C83.390.

  • Lymphomaprimary central nervous system(brain) (meninges) (PCNSL) (spinal cord)
  • Lymphomadiffuse large cellprimary central nervous system(brain) (meninges) (PCNSL) (spinal cord)
  • Lymphomaprimary central nervous systemdiffuse large B-cell

Related codes at this level

Codes that share C83.39. If C83.390 is not quite right, the correct code is usually one of these.

Questions about C83.390

Is C83.390 a billable ICD-10-CM code?
Yes. C83.390 is a billable, specific ICD-10-CM code and is valid for submission on a claim.
Where does C83.390 sit in the tabular list?
Neoplasms (C00-D49), in the block Malignant neoplasms of lymphoid, hematopoietic and related tissue (C81-C96).
What cannot be coded together with C83.390?
C83.390 carries an Excludes1 note, which means the conditions it lists can never be coded together with it on the same encounter.
ICD-10-CMFY2026-Apr· effective April 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release — see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.