MCMedicalCodingSoftware
C83.390

C83.390: Primary central nervous system lymphoma

Billable / specific codeICD-10-CM

C83.390 is a billable, specific ICD-10-CM code for primary central nervous system lymphoma. It is valid for submission on a claim.

Check C83.390 with the rest of the claim: free scrubber

Excludes1: never code together

These conditions cannot occur together. Billing both on the same encounter is a denial.

  • Primary central nervous system lymphoma, Burkitt (C83.79)
  • Primary central nervous system lymphoma, lymphoblastic (C83.59)
  • Primary central nervous system lymphoma, other (C83.89)
  • Primary central nervous system lymphoma, peripheral T-cell (C84.49)

Inclusion terms

Alternative wordings a physician may use in the chart for this same code.

  • PCNSL of brain
  • PCNSL of meninges
  • PCNSL of spinal cord
  • PCNSL NOS

Excludes1 inherited from the categories above C83.390

A category’s note binds every code beneath it.

Written on C83.3: Diffuse large B-cell lymphoma

  • mediastinal (thymic) large B-cell lymphoma (C85.2-)
  • mature T/NK-cell lymphomas (C84.-)

Written on C83: Non-follicular lymphoma

  • personal history of non-Hodgkin lymphoma (Z85.72)

Risk adjustment

C83.390 risk-adjusts. Under the CMS-HCC V28 model it maps to this category:

  • HCC 20 Lung and Other Severe Cancers1.136 RAF

Coefficient shown for the Community Non-dual Aged segment. A higher HCC in the same hierarchy will suppress this one, so capturing it does not always add score. Look up the whole chart to see which of its HCCs the hierarchy would zero.

Medicare coverage

C83.390 is named in 55 Medicare coverage policies: 55 listing it as supporting medical necessity. Which one applies depends on your Medicare contractor.

  • A52370Billing and Coding: Bevacizumab and biosimilars
  • A52479Oral Anticancer Drugs - Policy Article
  • A52480Oral Antiemetic Drugs (Replacement for Intravenous Antiemetics) - Policy Article
  • A53101Billing and Coding: MolDX: bioTheranostics Cancer TYPE ID® Update

Alphabetic index entries that lead here

  • Lymphoma›primary central nervous system(brain) (meninges) (PCNSL) (spinal cord)
  • Lymphoma›diffuse large cell›primary central nervous system(brain) (meninges) (PCNSL) (spinal cord)
  • Lymphoma›primary central nervous system›diffuse large B-cell

Code history

  • addedFY2024-FY2027

    Primary central nervous system lymphoma

Other codes under C83.39

ICD-10-CMFY2027· effective October 1, 2026

Loaded directly from the CMS/NCHS ICD-10-CM public-domain release: see data sources and our editorial policy. If this page disagrees with the CMS tabular list, this page is wrong. Reference information for professional coders; not medical or billing advice.