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ICD-10-CM tabular list

C00-C75Malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except neuroendocrine, and of lymphoid, hematopoietic and related tissue

ICD-10-CM codes C00-C75 cover malignant neoplasms, stated or presumed to be primary (of specified sites), and certain specified histologies, except neuroendocrine, and of lymphoid, hematopoietic and related tissue, within neoplasms. The block holds 791 codes across 12 sub-blocks, of which 603 are billable and 188 are header codes that cannot be submitted on a claim.

Risk adjustment in C00-C75

0 codes in this block map to a CMS-HCC, which means the diagnosis carries a risk-adjustment payment when it is documented and coded. Under-coding here is money left on the table; over-coding here is what audits are for.

  • HCC 21 Lymphoma and Other Cancers
  • HCC 23 Prostate, Breast, and Other Cancers and Tumors
  • HCC 22 Bladder, Colorectal, and Other Cancers
  • HCC 20 Lung and Other Severe Cancers
  • HCC 19 Myelodysplastic Syndromes, Multiple Myeloma, and Other Cancers

What else to watch in C00-C75

  • 202 codes are laterality-specific. They come in left and right pairs, and the pair is mutually exclusive on a single site: coding both without a bilateral code is a contradiction a scrubber should catch before the payer does.
  • 603 codes are named in Medicare coverage policies. An LCD or NCD lists them as supporting medical necessity, or explicitly as not supporting it. Which applies depends on the MAC for your state.

Blocks within C00-C75

ICD-10-CMFY2026-Apr· effective April 1, 2026