S0021: Injection, cefoperazone sodium, 1 gram
S0021 is a HCPCS Level II code for injection, cefoperazone sodium, 1 gram. It belongs to the Temporary National Codes (Non-Medicare) section. Medicare does not pay it: see the coverage note below before you bill it.
Medicare coverage: Not payable by Medicare
Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q4-Oct. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusI
Not valid for Medicare purposes. Medicare uses another code.
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
The CMS record for S0021
- Long descriptor
- Injection, cefoperazone sodium, 1 gram
- Short descriptor
- Injection, cefoperazone sod
- Added
- January 1, 2000
- BETOS
- Z2
- Pricing indicator
- 00: Not priced by Part B
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service: CMS's own analytic grouping.
Service not separately priced by Part B, not covered, bundled into another service, or used by Part A only.
Codes adjacent to S0021
HCPCS has no hierarchy: related items simply sit next to each other in the numbering. If S0021 is not quite right, the correct code is very often within a few positions of it.
- R0070Transportation of portable x-ray equipment and personnel to home or nursing home, per trip to facility or location, one patient seen
- R0075Transportation of portable x-ray equipment and personnel to home or nursing home, per trip to facility or location, more than one patient seen
- R0076Transportation of portable ekg to facility or location, per patient
- S0012Butorphanol tartrate, nasal spray, 25 mg
- S0013Esketamine, nasal spray, 1 mgterminated
- S0014Tacrine hydrochloride, 10 mg
- S0017Injection, aminocaproic acid, 5 gramsterminated
- S0020Injection, bupivicaine hydrochloride, 30 mlterminated
- S0023Injection, cimetidine hydrochloride, 300 mg
- S0028Injection, famotidine, 20 mgterminated
- S0030Injection, metronidazole, 500 mgterminated
- S0032Injection, nafcillin sodium, 2 gramsterminated
- S0034Injection, ofloxacin, 400 mg
- S0039Injection, sulfamethoxazole and trimethoprim, 10 mlterminated
- S0040Injection, ticarcillin disodium and clavulanate potassium, 3.1 grams
- S0073Injection, aztreonam, 500 mgterminated