S0021 — Injection, cefoperazone sodium, 1 gram
S0021 is a HCPCS Level II code for injection, cefoperazone sodium, 1 gram. It belongs to the Temporary National Codes (Non-Medicare) section. Medicare does not pay it — see the coverage note below before you bill it.
Medicare coverage: Not payable by Medicare
Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
Physician fee schedule statusI
Not valid for Medicare purposes. Medicare uses another code.
Global period: XXX
Want the dollar amount for your locality? The fee calculator applies your GPCI and the current conversion factor.
The CMS record for S0021
- Long descriptor
- Injection, cefoperazone sodium, 1 gram
- Short descriptor
- Injection, cefoperazone sod
- Added
- January 1, 2000
- BETOS
- Z2
- Pricing indicator
- 00 — Not priced by Part B
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Service not separately priced by Part B — not covered, bundled into another service, or used by Part A only.
Codes adjacent to S0021
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If S0021 is not quite right, the correct code is very often within a few positions of it.
- R0070Transportation of portable x-ray equipment and personnel to home or nursing home, per trip to facility or location, one patient seen
- R0075Transportation of portable x-ray equipment and personnel to home or nursing home, per trip to facility or location, more than one patient seen
- R0076Transportation of portable ekg to facility or location, per patient
- S0012Butorphanol tartrate, nasal spray, 25 mg
- S0013Esketamine, nasal spray, 1 mgterminated
- S0014Tacrine hydrochloride, 10 mg
- S0017Injection, aminocaproic acid, 5 gramsterminated
- S0020Injection, bupivicaine hydrochloride, 30 mlterminated
- S0023Injection, cimetidine hydrochloride, 300 mg
- S0028Injection, famotidine, 20 mgterminated
- S0030Injection, metronidazole, 500 mgterminated
- S0032Injection, nafcillin sodium, 2 gramsterminated
- S0034Injection, ofloxacin, 400 mg
- S0039Injection, sulfamethoxazole and trimethoprim, 10 mlterminated
- S0040Injection, ticarcillin disodium and clavulanate potassium, 3.1 grams
- S0073Injection, aztreonam, 500 mgterminated
Questions about S0021
What is HCPCS code S0021?
S0021 is a HCPCS Level II code for injection, cefoperazone sodium, 1 gram. It sits in the Temporary National Codes (Non-Medicare) section.
Does Medicare cover S0021?
The CMS HCPCS file marks S0021 as "Not payable by Medicare". Medicare does not pay this code. It may still be valid for another payer, but a Medicare claim carrying it will not be reimbursed.
How is S0021 paid under the physician fee schedule?
S0021 carries PFS status code I. Not valid for Medicare purposes. Medicare uses another code.