Q4100 — Skin substitute, not otherwise specified
Q4100 is a HCPCS Level II code for skin substitute, not otherwise specified. It belongs to the Temporary Codes section. It was terminated on December 31, 2025 and is not valid on new claims.
This code has been terminated
CMS terminated Q4100 on December 31, 2025. It stays in the file as history — a claim you are auditing from before that date may legitimately carry it — but it must not appear on a new claim. The adjacent codes below are the usual place to look for its replacement.
Medicare coverage: Carrier judgment
Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
From the coverage field of the CMS Alpha-Numeric HCPCS File, release 2026Q3-Jul. This states Medicare’s position on the code, not on your particular claim.
The CMS record for Q4100
- Long descriptor
- Skin substitute, not otherwise specified
- Short descriptor
- Skin substitute, nos
- Added
- January 1, 2009
- Terminated
- December 31, 2025
- BETOS
- O1E
- Pricing indicator
- 51 — Other
The official wording. This is what the code means.
CMS's 28-character form, which is what shows up on a remittance advice.
When CMS introduced the code.
When CMS retired it.
Berenson-Eggers Type of Service — CMS's own analytic grouping.
Drugs.
Codes adjacent to Q4100
HCPCS has no hierarchy — related items simply sit next to each other in the numbering. If Q4100 is not quite right, the correct code is very often within a few positions of it.
- Q4047Cast supplies, short leg splint, pediatric (0-10 years), plaster
- Q4048Cast supplies, short leg splint, pediatric (0-10 years), fiberglass
- Q4049Finger splint, static
- Q4050Cast supplies, for unlisted types and materials of casts
- Q4051Splint supplies, miscellaneous (includes thermoplastics, strapping, fasteners, padding and other supplies)
- Q4074Iloprost, inhalation solution, fda-approved final product, non-compounded, administered through dme, unit dose form, up to 20 micrograms
- Q4081Injection, epoetin alfa, 100 units (for esrd on dialysis)
- Q4082Drug or biological, not otherwise classified, part b drug competitive acquisition program (cap)
- Q4101Apligraf, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4102Oasis wound matrix, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4103Oasis burn matrix, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4104Integra bilayer matrix wound dressing (bmwd), per square centimeter (add-on, list separately in addition to primary procedure)
- Q4105Integra dermal regeneration template (drt) or integra omnigraft dermal regeneration matrix, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4106Dermagraft, per square centimeterterminated
- Q4107Graftjacket, per square centimeter (add-on, list separately in addition to primary procedure)
- Q4108Integra matrix, per square centimeter (add-on, list separately in addition to primary procedure)
Questions about Q4100
What is HCPCS code Q4100?
Q4100 is a HCPCS Level II code for skin substitute, not otherwise specified. It sits in the Temporary Codes section.
Does Medicare cover Q4100?
The CMS HCPCS file marks Q4100 as "Carrier judgment". Coverage is decided by your Medicare contractor, not by national policy. Whether this is paid depends on the LCD for your jurisdiction and on what the documentation supports.
Is Q4100 still valid?
No. Q4100 was terminated on December 31, 2025 and should not be used on new claims.